WHIM Publications
The publications listed below are offered for informational purposes only and do not represent all publications to which X4 Pharmaceuticals or its collaboration partners have contributed or may contribute or that relate to X4 Pharmaceuticals’ product candidates. These publications are made available by third parties, and the content of any linked third-party site is the responsibility of the third party, not X4 Pharmaceuticals, and X4 Pharmaceuticals disclaims liability for the linked content.
WHIM
N Engl J Med. 2019 Jan 10;380(2):163-170. doi: 10.1056/NEJMoa1808575.
Plerixafor for the Treatment of WHIM Syndrome.
McDermott DH, Pastrana DV, Calvo KR, Pittaluga S, Velez D, Cho E, Liu Q, Trout HH 3rd, Neves JF, Gardner PJ, Bianchi DA, Blair EA, Landon EM, Silva SL, Buck CB, Murphy PM.
J Allergy Clin Immunol Pract. 2019 May – Jun;7(5):1568-1577. doi: 10.1016/j.jaip.2019.01.045. Epub 2019 Feb 2.
Long-Term Outcome of WHIM Syndrome in 18 Patients: High Risk of Lung Disease and HPV-Related Malignancies.
Dotta L1, Notarangelo LD2, Moratto D3, Kumar R3, Porta F2, Soresina A4, Lougaris V5, Plebani A5, Smith CIE6, Norlin AC7, Gòmez Raccio AC8, Bubanska E9, Bertolini P10, Amendola G11, Visentini M12, Fiorilli M12, Venuti A13, Badolato R5.
Blood. 2017 Dec 7;130(23):2491-2498. doi: 10.1182/blood-2017-02-708552. Epub 2017 Oct 24.
How I treat warts, hypogammaglobulinemia, infections, and myelokathexis syndrome.
Badolato R1,2, Donadieu J3; WHIM Research Group.
Orphanet J Rare Dis. 2012 Sep 25;7:71. doi: 10.1186/1750-1172-7-71.
Description and outcome of a cohort of 8 patients with WHIM syndrome from the French Severe Chronic Neutropenia Registry.
Sarah Beaussant Cohen, Odile Fenneteau, Emmanuel Plouvier, Pierre-Simon Rohrlich, Gerard Daltroff, Isabelle Plantier, Alain Dupuy, Delphine Kerob, Blandine Beaupain, Pierre Bordigoni, Fanny Fouyssac,
Anne-Lise Delezoide, Gilles Devouassoux, Jean François Nicolas, Philippe Bensaid, Yves Bertrand, Karl Balabanian, Christine Bellanne Chantelot, Françoise Bachelerie , Jean Donadieu.
Blood. 2011 Nov 3;118(18):4957-62. doi: 10.1182/blood-2011-07-368084. Epub 2011 Sep 2.
The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome.
McDermott DH1, Liu Q, Ulrick J, Kwatemaa N, Anaya-O’Brien S, Penzak SR, Filho JO, Priel DA, Kelly C, Garofalo M, Littel P, Marquesen MM, Hilligoss D, Decastro R, Fleisher TA, Kuhns DB, Malech HL, Murphy PM.
Clin Immunol. 2010 Jun;135(3):412-21. doi: 10.1016/j.clim.2010.02.006. Epub 2010 Mar 11.
Oligoclonality, impaired class switch and B-cell memory responses in WHIM syndrome.
Mc Guire PJ1, Cunningham-Rundles C, Ochs H, Diaz GA.
Blood. 2004 Jul 15;104(2):444-52. Epub 2004 Mar 16.
Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome.
Gulino AV1, Moratto D, Sozzani S, Cavadini P, Otero K, Tassone L, Imberti L, Pirovano S, Notarangelo LD, Soresina R, Mazzolari E, Nelson DL, Notarangelo LD, Badolato R.
Nat Genet. 2003 May;34(1):70-4.
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease.
Hernandez PA1, Gorlin RJ, Lukens JN, Taniuchi S, Bohinjec J, Francois F, Klotman ME, Diaz GA.
Primary Immunodeficiencies
Clin Rev Allergy Immunol. 2014 Apr;46(2):145-53. doi: 10.1007/s12016-013-8380-0.
New genetic discoveries and primary immune deficiencies.
Hernandez-Trujillo V1.
J Clin Immunol. 2007 Sep;27(5):497-502. Epub 2007 Jun 19.
Population prevalence of diagnosed primary immunodeficiency diseases in the United States.
Boyle JM1, Buckley RH.
J Allergy Clin Immunol. 2012 Nov;130(5):1030-48. doi: 10.1016/j.jaci.2012.07.049. Epub 2012 Oct 1.
Warts and all: human papillomavirus in primary immunodeficiencies.
Leiding JW1, Holland SM.
Blood. 2010 Oct 14;116(15):2793-802. doi: 10.1182/blood-2010-01-265942. Epub 2010 Jul 8.