Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision
  • Say what they mean, and let their words match their actions
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

Open Positions

Medical Director, Rare Disease

X4 Pharmaceuticals is developing novel medicines designed to improve immune cell trafficking and restore healthy immunity in certain rare, genetic primary immunodeficiency diseases and lymphomas.

Our oral, small molecule therapeutics antagonize the C-X-C receptor type 4 (CXCR4) pathway which plays a central role in immune surveillance. We are leveraging our unique assets and understanding of the CXCR4 pathway to pursue a rare disease strategy for developing and commercializing new treatments for patients who lack effective treatment options.

X4’s most advanced product candidate, X4P-001, is in a Phase 2/3 clinical trial in patients with WHIM syndrome, a rare genetic, primary immunodeficiency disease. Clinical programs for X4P‑001 are also advancing in other rare, genetic immunodeficiency diseases, as well as in certain rare leukemias and lymphomas. Additional programs advancing in X4’s pipeline include another CXCR4 antagonist for primary immunodeficiencies, and a CXCR4-targeted candidate that crossed the blood-brain-barrier that is designed specifically for the treatment of brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Chief Medical Officer, the Medical Director, Rare Disease is responsible for developing and implementing the global strategy and tactical plans and recruitment plans for our Ph 3 trial in rare primary immunodeficiency disease program. As an emerging leader and content expert in our disease, WHIM (Warts, Hypogammaglobulinemia, Infections and Myelokathexis) Syndrome, the Medical Director will align with the Clinical Operations and Medical Affairs teams to identify and learn from the WHIMS medical and patient communities to inform and execute our clinical trial strategy and success.  The candidate will engage and establish credibility with the community and lead this program to ensure strategic alignment and execution of internal and external priorities and activities. This position ensures rigorous scientific interactions with investigators, KOLs, and patient advocacy organizations.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.  

Scope of Work and Responsibilities: 

  • Serve as primary Medical leader for the Immunodeficiency Program. Lead, develop and implement the rare disease medical strategy through strong engagement and learning from the medical and patient communities, KOL identification and long-term relationship management
  • Lead, develop and implement the Phase 2/3 study for WHIM
  • Create and disseminate medical and research outcomes through publications and education material
  • Proactively identify program risks, and create and implement mitigation strategies
  • Handle day-to-day clinical, medical, and scientific questions from various internal and external sources
  • Participate in the ongoing interpretation and analysis of clinical trial results including human pharmacokinetics, pharmacodynamics, laboratory and biomarker data, review and approve clinical trial coding, and safety monitoring
  • Collaborate cross-functionally in the preparation of the CDP, briefing books for health authority interactions, clinical protocols, investigator brochures, target product profiles, annual IND reports, severe adverse event reports, periodic safety update reports, clinical study reports
  • Participate as medical lead in various meetings with the EMA and FDA, or other Regulatory bodies
  • Coordinate activities related to collection of natural history data, patient advocacy, and medical education
  • Continual review and analysis of the pertinent medical (disease-specific) literature
  • Preparation and/or delivery of abstracts, posters, and slide presentation at external Conference Symposia, and manuscripts for peer-reviewed journals
  • Travel ~ 30% of the time representing X4 at global   medical, patient advocacy and advisory meetings, conferences and advisory boards; collaborates with thought leaders to ensure the integrity of information exchange and to significantly increase the X4 fingerprint in the communities.

 

Qualifications and Professional Skills:

 

  • M.D. board certified, immunology a plus
  • Minimum 7 years industry experience in rare disease biotech or biopharma, immunology a plus
  • Demonstrated ability to meaningfully contribute to development strategy and then own and deliver on tactical implementation of strategy.
  • Ability to travel ~ 30% of the time
  • Successful history working effectively with FDA and other global regulatory agencies
  • Experience leading and managing clinical development programs through Phase 3
  • Exemplary written, verbal and electronic communications skills with diverse audiences
  • Proven success working with and effectively supporting cross-functional teams
  • Reputation for a collaborative and transparent leadership style
  • Strong analytical approach to problem-solving
  • Knowledge of global regulatory climate
  • Reputation for rigorous science and highest ethics

The above statements are intended to describe the general nature and level of work being performed.  They are not intended to be construed as an exhaustive list of all responsibilities. 

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce.  All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.   Please send your resume and cover letter to careers@x4pharma.com.

Director/Senior Director, Quality

X4 Pharmaceuticals is developing novel medicines designed to improve immune cell trafficking and restore healthy immunity in certain rare, genetic primary immunodeficiency diseases and lymphomas.

Our oral, small molecule therapeutics antagonize the C-X-C receptor type 4 (CXCR4) pathway which plays a central role in immune surveillance. We are leveraging our unique assets and understanding of the CXCR4 pathway to pursue a rare disease strategy for developing and commercializing new treatments for patients who lack effective treatment options.

X4’s most advanced product candidate, X4P-001, is in a Phase 2/3 clinical trial in patients with WHIM syndrome, a rare genetic, primary immunodeficiency disease. Clinical programs for X4P‑001 are also advancing in other rare, genetic immunodeficiency diseases, as well as in certain rare leukemias and lymphomas. Additional programs advancing in X4’s pipeline include another CXCR4 antagonist for primary immunodeficiencies, and a CXCR4-targeted candidate that crossed the blood-brain-barrier that is designed specifically for the treatment of brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Vice President, Technical Operations & Quality, the Director/Senior Director, Quality will be responsible for building and leading the Quality function for our rapidly growing company.  The position is responsible for establishing and implementing global quality systems and assuring GXP compliance and strategic risk mitigation across the company, both internally and in collaboration with our vendors and partners. The qualified candidate has experience building and maintaining sustained and trusting cross-functional relationships with key strategic internal and external stakeholders, and has earned a strong reputation supporting development programs from preclinical through commercialization.

The Leader of the function is the key point person to address, escalate and resolve quality issues raised internally and externally at all levels of the organization.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

Scope of Work and Responsibilities: 

  • Build, improve and implement quality systems and standards to support global regulatory compliance and industry expectations
  • Develop and grow the Quality function, with a blend of internal and consulting resources, to identify, communicate and maintain appropriate quality standards, reduce corporate risk and meet corporate objectives
  • As internal Subject Matter Expert, ensure corporate quality philosophy and expectations are recognized, understood and implemented across the company through continual communications, training, and alignment
  • Effectively collaborate and lead across all relevant disciplines (eg. manufacturing, clinical, nonclinical, regulatory) to ensure an appropriate state of compliance and inspection readiness
  • Direct all Quality operations activities for the disposition of products, implement change control and lead investigations as required
  • Provide Quality framework, resources, and expectations to oversee consultant and vendor qualification and compliance audits
  • Develop, provide and document required systematic GXP training for employees and external personnel, as necessary
  • Collaboratively manage the development, review, and approval of SOPs in compliance with applicable regulatory requirements
  • Communicate corporate Quality status, active initiatives, and metrics through leadership of a regular management review forum
  • Provide timely Quality leadership to the CMC team to ensure risk reduction
  • Proactively review and interpret quality regulations and guidelines, continually advise the management team of critical business implications and risks
  • Provide strategic insight to annual, long-range planning, and budgetary process ensuring timely, effective use of resources, including management of consultants

Qualifications and Professional Skills: 

Proven ability to thrive working in a fast-paced, innovative environment while remaining flexible, proactive, resourceful and efficient. Proven successes working through complex business challenges. Excellent written, verbal and electronic communication skills. Experience developing effective relationships with key stakeholders at all levels of the organization including the successful application of conflict resolution and negotiation skills. Proven ability to analyze scientific issues and develop relevant and realistic recommendations and plans.

  • Bachelor’s degree with 15+ years, MS or D. with 10+ years relevant industry experience. Extended experience in a QA function. Advanced degree preferred. Experience in a technical, small molecule line-function strongly preferred
  • Proven exceptional leadership and managerial skills and demonstrated experience working across functions and levels. Ability to work both strategically and tactically
  • Strong GMP experience with an in-depth understanding of all aspects of technical development and manufacturing from preclinical through commercialization, including validation
  • Broad knowledge of compliance regulations and experience or exposure to a broad Quality organization responsible for clinical, nonclinical and manufacturing compliance
  • Direct experience with global health authority inspections
  • Strong analytical skills with practical knowledge of how to identify, manage and communicate key quality performance metrics
  • Direct experience successfully working with outsourced manufacturing and testing operations.
  • Managerial experience with proven organizational and leadership skills to mentor and develop teams
  • Success and experience working in both large and small organizations, and in all phases of clinical development, strongly preferred

The above statements are intended to describe the general nature and level of work being performed.  They are not intended to be construed as an exhaustive list of all responsibilities. 

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce.  All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.   Please send your resume and cover letter to careers@x4pharma.com.  

Associate Director, Regulatory Affairs

X4 Pharmaceuticals is developing novel medicines designed to improve immune cell trafficking and restore healthy immunity in certain rare, genetic primary immunodeficiency diseases and lymphomas.

Our oral, small molecule therapeutics antagonize the C-X-C receptor type 4 (CXCR4) pathway which plays a central role in immune surveillance. We are leveraging our unique assets and understanding of the CXCR4 pathway to pursue a rare disease strategy for developing and commercializing new treatments for patients who lack effective treatment options.

X4’s most advanced product candidate, X4P-001, is in a Phase 2/3 clinical trial in patients with WHIM syndrome, a rare genetic, primary immunodeficiency disease. Clinical programs for X4P‑001 are also advancing in other rare, genetic immunodeficiency diseases, as well as in certain rare leukemias and lymphomas. Additional programs advancing in X4’s pipeline include another CXCR4 antagonist for primary immunodeficiencies, and a CXCR4-targeted candidate that crossed the blood-brain-barrier that is designed specifically for the treatment of brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Vice President, Regulatory Affairs, the Associate Director, Regulatory Affairs will be responsible for overseeing the global regulatory strategic plans for the development of current and future indications. The individual must possess excellent judgment, organizational and planning skills along with exceptional written and verbal communications. The successful candidate will also have the ability to influence and negotiate professionally at various levels within the project team and with external partners while maintaining positive working relationships.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

 Scope of Work and Responsibilities: 

  • Accountable and responsible for evaluating and ensuring that IND/IMPD/NDA and other filings meet all global regulatory requirements throughout the drug development process. Ensures that safety reporting requirements, annual reporting, and routine updates are met within the regulatory timeframes.
  • Represent regulatory affairs at various clinical trial team meetings and provide regulatory content reviews of clinical documents, such as new or revised protocols, patient informed consent forms, investigator’s brochures.
  • Lead the development and maintenance of global regulatory strategy documents and target product profiles to support new marketing application planning and development. Research regulatory precedence of prior approvals, clinical trial endpoints and compare competitor labeling documents.
  • Consistently and proactively research and learn FDA and EMA regulation, guidance and standards to anticipate and resolve regulatory and clinical development questions, as needed, throughout the drug development process. Provide timely dissemination of regulatory intelligence, as appropriate to continually educate and inform project team(s).
  • Translate and integrate strategies into the global regulatory submissions operations needs working with a vendor to ensure that all electronic submissions meet global regulatory standards, including the development of submission content plans, submission component development, compilation, and quality checks of documents prior to submission to regulatory agencies. Maintain and update regulatory files to ensure chronologies remain in good order and implement a system for tracking global IND/IMPD/NDA and other submissions and changes.
  • Responsible and accountable for communicating and driving timelines, risks, and ensuring that submission components are completed within the expected timeframe. Provide regulatory support in drafting responses to global agency requests for information, and briefing document development for Agency meetings, and ensure that next level management remains apprised of any changes to the plan along the way.
  • May supervise regulatory affairs consultants, as required.

Qualifications and Professional Skills: 

  • BA degree in a science discipline or related discipline
  • 5+ years of relevant experience within the Regulatory Affairs discipline of a life sciences company
  • Knowledge of US and international regulatory requirements
  • Marketing application submission experience, Agency interactions, and knowledge of orphan drug development are a plus
  • Demonstrated ability to think critically and analyze scientific information while paying close attention to detail

The above statements are intended to describe the general nature and level of work being performed.  They are not intended to be construed as an exhaustive list of all responsibilities. 

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce.  All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.   Please send your resume and cover letter to careers@x4pharma.com.  

Senior Manager, Accounting & Assistant Corporate Controller

X4 Pharmaceuticals is developing novel medicines designed to improve immune cell trafficking and restore healthy immunity in certain rare, genetic primary immunodeficiency diseases and lymphomas.

Our oral, small molecule therapeutics antagonize the C-X-C receptor type 4 (CXCR4) pathway which plays a central role in immune surveillance. We are leveraging our unique assets and understanding of the CXCR4 pathway to pursue a rare disease strategy for developing and commercializing new treatments for patients who lack effective treatment options.

X4’s most advanced product candidate, X4P-001, is in a Phase 2/3 clinical trial in patients with WHIM syndrome, a rare genetic, primary immunodeficiency disease. Clinical programs for X4P‑001 are also advancing in other rare, genetic immunodeficiency diseases, as well as in certain rare leukemias and lymphomas. Additional programs advancing in X4’s pipeline include another CXCR4 antagonist for primary immunodeficiencies, and a CXCR4-targeted candidate that crossed the blood-brain-barrier that is designed specifically for the treatment of brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Senior Director, Finance & Corporate Controllers, the Senior Manager, Accounting & Assistant Controller will be responsible for managing the monthly accounting close and all SEC reporting and filings. The individual will be responsible for multi-tasking on many projects and deliverables.  The Sr. Accounting Manager will have senior executive exposure and will work with legal, auditors and others on a regular basis.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

Scope of Work and Responsibilities: 

  • Drives timely preparation and review of monthly, quarterly and year-end financial statements
  • Directs and oversees the preparation, review, submission, and distribution of financial reports required by government and regulatory agencies, such as US SEC, 10-Q, 10-K, 8-K, and other ad hoc filings
  • Liaises and manages relationship and activities with external auditors as part of the financial reporting process
  • Lead the implementation efforts and ongoing monitoring of significant new pronouncements
  • Partner with internal business units for financial report preparation and accounting needs
  • Administers company employee stock option plans and capitalization table
  • Preparation of financial materials used in communications to the Audit Committee, Board of Directors and Senior Management
  • Assume the lead role in managing internal controls and compliance programs
  • Assist the Controller with all relevant corporate tax areas and be a liaison with the third-party accounting firm engaged in the corporate tax function
  • Complete, document and communicate and/or present ad-hoc projects and analysis

Qualifications and Professional Skills: 

  • Bachelor’s degree in Accounting required with a minimum of 7 years’ experience working for a public company
  • Experience in biotechnology or pharmaceuticals industries preferred but not required
  • Public accounting experience and CPA required
  • Technical expertise related to GAAP and external reporting including SEC reporting, stock-based compensation accounting, and internal control requirements
  • Demonstrated recent experience in researching and preparing technical accounting memorandums for complex issues and new pronouncements
  • Understanding of accounting policies, processes, procedures, and internal controls
  • Experience with general ledger functions and the month-end/year-end close process
  • Knowledge of automated financial reporting and accounting systems
  • Ability to adapt quickly and learn new tasks independently
  • Ability to manage competing priorities and in order to meet deadlines
  • Excellent verbal and written communication skills, ability to work across levels, functions, companies, and countries.
  • Demonstrates a sense of urgency, proactive thinking, and productivity in a fast-paced, entrepreneurial and team-oriented environment.

The above statements are intended to describe the general nature and level of work being performed.  They are not intended to be construed as an exhaustive list of all responsibilities. 

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce.  All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.   Please send your resume and cover letter to careers@x4pharma.com.  

We invite you to apply for any of our current openings at careers@x4pharma.com for additional employment related information.