Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision.
  • Say what they mean, and let their words match their actions.
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

Open Positions

Director, Non-Clinical Development

Company Description:

 X4 Pharmaceuticals is developing novel therapeutics designed to improve immune cell trafficking including the ability for T-cells to track and destroy cancer cells. Our small molecule drug candidates inhibit C-X-C receptor type 4 (CXCR4), a receptor over-expressed in many cancers. Inhibition of CXCR4 is designed to block non-cancerous immunosuppressive and pro-angiogenic cells from populating the tumor, disrupting the cancer microenvironment and restoring normal immune surveillance functions. We are committed to advancing the field of cancer immunotherapy and immune disorders through innovation and investment in our proprietary clinical and preclinical pipeline.

The Director, Non-Clinical Development, reporting to the Chief Medical Officer, is a highly visible role as a technical and subject matter expert at X4. The Director will be responsible for developing and implementing the company’s preclinical drug development strategy—drug metabolism, pharmacokinetics and toxicology—from candidate identification through approval. This position will provide leadership and support to internal and external project teams with cross-functional interactions across Research and Development, Clinical, Regulatory, Technical Operations and Quality to ensure that the business meets critical milestones and objectives. Working in a virtual environment, the Director, Non-Clinical Development will work both strategically and tactically, selecting and integrating Contract Research Organization (CRO) activities into internal program plans and assuring Regulatory and Quality expectations are met.

Scope of Work and Responsibilities: 

  • Collaborate with research project leaders to develop and implement strategies generating data to support development candidate nomination and transition to IND-enabling studies.
  • Design and manage non-GLP and GLP studies to support IND submissions, including ADME, PK, biodistribution and toxicology.
  • Build and implement preclinical strategies and plans to support clinical development and global regulatory plans to licensure application.
  • Lead and manage a Preclinical function within corporate growth and development plans and objectives. Oversee the selection and management of consultants and CROs to support development programs.
  • Manage projects conducted by CROs with efficient governance including contract execution, authorization of study amendments, schedule and budget variance management, progress reporting to stakeholders, review of data and draft study reports, completion of contract milestones, study close out and alignment of preclinical development efforts with corporate drug development efforts and priorities.
  • Maintain primary accountability for the messaging, development and approval of regulatory filing documents. Represent preclinical information and positions in agency meetings and communications.
  • Represent a preclinical function on cross functional program teams, contribute to program development plans and timelines, and contribute to clinical development plans.
  • Work closely with regulatory, clinical and drug safety to establish safety monitoring plans in clinical trials based on preclinical findings.
  • Work closely with Technical Operations to assure appropriate supply, characterization, stability, shipment and storage to support preclinical studies.
  • In collaboration with Quality and Regulatory, assure compliance with GXP and regulatory standards and guidelines.
  • Balance the expectations, challenges and responsibility of a critical compliance function within a small but fast growing virtual organization.
  • Travel sufficient to develop and build strong partnerships with CROs (estimated at approximately 20%).

Qualifications and Professional Skills:

  • PhD, DVM or equivalent with accomplished experience in pharmacology, drug metabolism, toxicology or pathology.
  • Solid understanding of the drug discovery and development process based on at least 8 years of relevant experience in the biotechnology or pharmaceutical industry. Experience with both early and late stage development programs and a demonstrable ability to identify and resolve complex development challenges.
  • Experience with the design and execution of in vitro/in vivo studies to determine the effects of therapeutics on biological systems in context of drug development in humans.
  • In-depth understanding of approaches to elucidate and fully characterize molecular mechanisms of drug action.
  • Direct experience writing regulatory documents and interfacing with global regulatory agencies. Working knowledge of GLP, GCP, GMP and ICH guidelines.
  • Significant experience working with CROs through the various stages of drug development. Participating in vendor selection, developing scopes of work, participating on virtual teams, planning and reviewing technical content, leading technical and data-based decision making, negotiating plans, and holding CROs accountable for delivery.
  • Demonstrated success leading and working in global, cross-functional teams.
  • Strong leadership, team building, organizational, communication, and interpersonal skills. Able to apply a strategic view, as well as hands-on problem-solving skills.
  • Excellent verbal and written communication skills, ability to work across levels, functions and companies.
  • A strong team player that has a customer service approach and is solution oriented.
  • Demonstrates a sense of urgency, proactive thinking, and productivity in a fast-paced entrepreneurial environment.

The above statements are intended to describe the general nature and level of work being performed.  They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce.  All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.   Please send your resume and cover letter to careers@x4pharma.com.  

Medical Director, Clinical Development, Rare Disease

Company Description:

X4 Pharmaceuticals is developing novel therapeutics designed to improve immune cell trafficking including the ability for T-cells to track and destroy cancer cells. Our small molecule drug candidates inhibit C-X-C receptor type 4 (CXCR4), a receptor over-expressed in many cancers. Inhibition of CXCR4 is designed to block non-cancerous immunosuppressive and pro-angiogenic cells from populating the tumor, disrupting the cancer microenvironment and restoring normal immune surveillance functions. We are committed to advancing the field of cancer immunotherapy and immune disorders through innovation and investment in our proprietary clinical and preclinical pipeline.

The position:

Reporting to the Chief Medical Officer, the Medical Director, Clinical Development, Rare Disease is responsible for developing and implementing the global clinical strategy and tactical plans in a rare primary immunodeficiency disease program. As an emerging leader and content expert in our disease, WHIM (Warts, Hypogammaglobulinemia, Infections and Myelokathexis) Syndrome, the person will identify and learn from the WHIMS’ medical and patient communities to inform and execute our plans. Along with the Senior Director, Medical Affairs the person will engage and establish credibility with the medical community and lead this program to ensure strategic alignment and execution of internal and external priorities and activities. This position ensures rigorous scientific interactions with investigators, KOLs, and global regulators.

This is a unique opportunity to have a huge impact on a population of patients who are often undiagnosed or misdiagnosed. The successful candidate must be a leader who is a passionate drug developer driven to help patients, can inspire both internally/externally, has a creative mindset, is able to effectively succeed in ambiguity and has the appetite to grow with the organization.  This role also offers a high level of visibility across the leadership team and will have an impactful role on X4’s most advanced program.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

Scope or Work and Responsibilities:

  • Serve as primary Medical and Clinical lead for the Immunodeficiency Program. Lead, develop and implement the rare disease medical strategy through strong engagement internally and learning from the medical and patient communities.
  • Lead, develop and implement the Phase 2/3 study for WHIM.
  • Proactively identify program risks, and create and implement mitigation strategies.
  • Accountable for the day-to-day clinical, medical and scientific questions from various internal and external sources.
  • Participate in the ongoing interpretation and analysis of clinical trial results including human pharmacokinetics, pharmacodynamics, laboratory and biomarker data, review and approve clinical trial coding, and safety monitoring.
  • Collaborate cross-functionally in the preparation of the CDP, briefing books for health authority interactions, clinical protocols, investigator brochures, target product profiles, annual IND reports, severe adverse advent reports, periodic safety update reports, clinical study reports.
  • Participate as medical lead in various meetings with the EMA and FDA, or other regulatory bodies.
  • Timely reviews and analysis of the pertinent medical (disease-specific) literature.
  • Work with Senior Director, Medical Affairs to prepare and/or deliver abstracts, posters, and slide presentations at external Conference Symposia, and manuscripts for peer-reviewed journals.
  • Collaborate with Senior Director, Medical Affairs in representing X4 at global medical and advisory meetings, conferences and advisory boards; collaborates with thought leaders to ensure the integrity of information exchange and to significantly increase the X4 fingerprint in the communities.

Professional and personal profile: 

  • MD is required, board certification in immunology a plus
  • Highly accomplished and credible clinical development background within the biotech or pharma industry, experience in rare diseases preferred
  • Demonstrated ability to meaningfully contribute to development strategy and own and deliver on tactical implementation of strategy
  • Successful history working effectively with FDA and other global regulatory agencies
  • Experience leading and managing clinical development programs up to Phase 3
  • Exemplary written, verbal and electronic communications skills with diverse audiences
  • Proven success working with and effectively supporting cross-functional teams
  • Reputation for a collaborative and transparent leadership style
  • Strong analytical approach to problem solving
  • Knowledge of global regulatory climate
  • Reputation for rigorous science and highest ethics

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. 

Qualified candidates please apply to careers@x4pharma.com

We invite you to apply for any of our current openings at careers@x4pharma.com for additional employment related information.