Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision.
  • Say what they mean, and let their words match their actions.
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

Open Positions

Director, Pharmacovigilance

Reports to: CMO

Company Description:

X4 Pharmaceuticals is developing novel therapeutics designed to improve immune cell trafficking including the ability for T-cells to track and destroy cancer cells. Our small molecule drug candidates inhibit C-X-C receptor type 4 (CXCR4), a receptor over-expressed in many cancers. Inhibition of CXCR4 is designed to block non-cancerous immunosuppressive and pro-angiogenic cells from populating the tumor, disrupting the cancer microenvironment and restoring normal immune surveillance functions. We are committed to advancing the field of cancer immunotherapy and immune disorders through innovation and investment in our proprietary clinical and preclinical pipeline.

To succeed at X4, the candidate will have a sustained reputation for a values-driven, collaborative, engagement style where integrity and the consideration of our Patients drives all decisions and actions.

X4 Pharmaceuticals is seeking an experienced Pharmacovigilance (PV) Operations professional who is a creative, resourceful and integrative thinker.  This position is responsible for creating, directing and managing the company’s infrastructure to support the operational aspects of the pharmacovigilance system and adheres to all global safety requirements and internal processes and procedures.  The qualified candidate will have experience in and perform multiple activities related to X4 case management, data review, document development and review including procedures for the accurate and timely processing, review and reporting of adverse events from investigational X4 compounds and X4 marketed products.  In addition, this position will build and maintain sustained and trusting relationships with key strategic internal and external stakeholders, including provide leadership for interactions with health authorities, support review and development of regulatory submissions and PV activities.

Scope of Work and Responsibilities:

  • Responsible for building, developing and managing external resources allocated to operational PV activities, creating a highly efficient, team to include insourced and outsourced resources, as needed.
  • Contribute to the development of global Medical Safety/Pharmacovigilance strategies.
  • Build, implement, and ensure regulatory compliance with domestic and international pharmacovigilance systems, regulations, and industry standards
  • Contribute to the identification and selection of PV vendors to support the current outsourced PV business model. Provide vendor oversight and management for all PV activities, including establishing and monitoring key quality and compliance metrics.
  • Establish a system for prevention and timely correction of deviation to compliance with stakeholders, in collaboration with the PV Quality, Compliance and Safety Systems group and QA team. Support development of functional area SOPs/WIs/Company Safety Governance Policy
  • Oversee the set-up of new safety projects, including development of study-specific Safety Management Plans and set up of safety systems and database configurations in the PV database to accommodate these trials and products.
  • Develop and/or maintain a set of SOPs related to the processing and reporting of SAEs from clinical trials and marketed products, when relevant to ensure performant and compliant PV processing, integrated with other PV and non- PV SOPs.
  • Contribute to the signal detection, benefit-risk profile assessment and aggregate reporting activities by providing accurate reports from the PV database.
  • Responsible for a compliant and quality execution of all operational activities related to case management and related activities. Oversees timely submissions of expedited reports to the FDA & other health authorities. Lead authorship and cross functional review of developmental safety update reports (DSURs)
  • Identifies deviations and applicable corrective and preventive actions immediately to maintain the compliance reporting at its highest level.
  • Develop and implement an inspection readiness program with the contribution of other PV and non-PV stakeholders.
  • Ensure that the PV Database supports the department needs, including specific workflows and reporting/querying functionalities. Provide oversight of systems and MedDRA updates in collaboration with the relevant PV Vendor.
  • Represents drug safety as a leader on project teams and committees, as needed.

Qualifications and Specialized Knowledge and Skills:

The candidate must thrive working in a fast-paced, innovative environment while remaining flexible, proactive, resourceful and efficient.  Excellent interpersonal skills, experience developing strategic and long- term relationships with key stakeholders, tested conflict management and negotiation skills are required.  The ability to analyze complex issues to develop relevant and realistic plans, programs and recommendations is required. We are seeking someone with a demonstrated ability to translate strategy into action, excellent analytical skills, an ability to communicate complex issues clearly to a broad group of people and experience orchestrating plans to resolve issues and mitigate risks.

  • Bachelor’s degree in life sciences, pharmacy, nursing or equivalent health experience; advanced Life Sciences Degree or MBA preferred.
  • Minimum of 3-5 years of experience in Drug Safety / Pharmacovigilance role in the biotech or pharmaceutical industry.
  • Demonstrated ability to create, evaluate and maintain effective business processes, implement procedures, systems and tools to maximize budget and resources within a Drug Safety department.
  • Thorough knowledge and experience in all aspects of global safety reporting for clinical trials through commercialization.
  • Strong knowledge and experience with currently available drug safety database systems, document management systems and QC tools. This also includes MedDRA and linked technologies.
  • Operational expertise with safety databases such as ARGUS is preferred.
  • Experience in supporting regulatory agency meetings and/or inspections is a plus
  • Excellent oral, electronic and written communication skills.
  • Strong interpersonal, collaboration and leadership skills and demonstrated ability to motivate and influence work behaviors of individuals who are not direct reports.
  • A reputation that reflects embracing the core values and the mission of X4.

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities. 

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. 

Qualified candidates please send cover letter and resume to careers@x4pharma.com 

Medical Director, Rare Disease

Company Description:

X4 Pharmaceuticals is developing novel therapeutics designed to improve immune cell trafficking including the ability for T-cells to track and destroy cancer cells. Our small molecule drug candidates inhibit C-X-C receptor type 4 (CXCR4), a receptor over-expressed in many cancers. Inhibition of CXCR4 is designed to block non-cancerous immunosuppressive and pro-angiogenic cells from populating the tumor, disrupting the cancer microenvironment and restoring normal immune surveillance functions. We are committed to advancing the field of cancer immunotherapy and immune disorders through innovation and investment in our proprietary clinical and preclinical pipeline.

The position:

Reporting to the Chief Medical Officer, Sudha Parasuraman, the Medical Director/ Senior Medical Director, Rare Disease is responsible for developing and implementing the global strategy and tactical plans in a rare primary immunodeficiency disease program. As an emerging leader and content expert in our disease, WHIM (Warts, Hypogammaglobulinemia, Infections and Myelokathexis) Syndrome, the incumbent will identify and learn from the WHIMS medical and patient communities to inform and execute our plans. The role holder will engage and establish credibility with the community and lead this program to ensure strategic alignment and execution of internal and external priorities and activities. This position ensures rigorous scientific interactions with investigators, KOLs, and patient advocacy organizations.

This will be a unique opportunity to have a huge impact on a population of patients who are often undiagnosed or misdiagnosed. The incumbent must be a leader that can inspire both internally/externally, has a creative mindset, can deal with ambiguity, has the appetite to grow with the entire organization, and is a passionate drug developer. This role also offers a high level of visibility across the leadership team and will have an impactful role on X4’s most advanced program currently.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

Scope or Work and Responsibilities:

  • Serve as primary Medical leader for the Immunodeficiency Program. Lead, develop and implement the rare disease medical strategy through strong engagement and learning from the medical and patient communities, KOL identification and long- term relationship management
  • Lead, develop and implement the Phase 2/3 study for WHIM
  • Create and disseminate medical and research outcomes through publications and education material
  • Proactively identify program risks, and create and implement mitigation strategies
  • Handle day-to-day clinical, medical, and scientific questions from various internal and external sources
  • Participate in the ongoing interpretation and analysis of clinical trial results including human pharmacokinetics, pharmacodynamics, laboratory and biomarker data, review and approve clinical trial coding, and safety monitoring
  • Collaborate cross-functionally in the preparation of the CDP, briefing books for health authority interactions, clinical protocols, investigator brochures, target product profiles, annual IND reports, severe adverse advent reports, periodic safety update reports, clinical study reports
  • Participate as medical lead in various meetings with the EMA and FDA, or other regulatory bodies
  • Coordinate activities related to collection of natural history data, patient advocacy, and medical education
  • Continual review and analysis of the pertinent medical (disease-specific) literature
  • Preparation and/or delivery of abstracts, posters, and slide presentation at external Conference Symposia, and manuscripts for peer-reviewed journals
  • Travel ~ 30% of the time representing X4 at global medical, patient advocacy and advisory meetings, conferences and advisory boards; collaborates with thought leaders to ensure the integrity of information exchange and to significantly increase the X4 fingerprint in the communities

Professional and personal profile: 

  • MD is required, board certification in immunology would be a plus
  • Highly accomplished and credible clinical development background within industry having experience in rare diseases
  • Demonstrated ability to meaningfully contribute to development strategy and then own and deliver on tactical implementation of strategy
  • Ability to travel ~ 30% of the time
  • Successful history working effectively with FDA and other global regulatory agencies
  • Experience leading and managing clinical development programs up to Phase 3
  • Exemplary written, verbal and electronic communications skills with diverse audiences
  • Proven success working with and effectively supporting cross-functional teams
  • Reputation for a collaborative and transparent leadership style
  • Strong analytical approach to problem solving
  • Knowledge of global regulatory climate
  • Reputation for rigorous science and highest ethics

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. 

Qualified candidates please apply to careers@x4pharma.com

Senior Accountant

Company Description:

X4 Pharmaceuticals is developing novel therapeutics designed to improve immune cell trafficking including the ability for T-cells to track and destroy cancer cells. Our small molecule drug candidates inhibit C-X-C receptor type 4 (CXCR4), a receptor over-expressed in many cancers. Inhibition of CXCR4 is designed to block non-cancerous immunosuppressive and pro-angiogenic cells from populating the tumor, disrupting the cancer microenvironment and restoring normal immune surveillance functions. We are committed to advancing the field of cancer immunotherapy and immune disorders through innovation and investment in our proprietary clinical and preclinical pipeline.

Reporting to the Controller/Sr. Director Finance, the Senior Accountant will have responsibility for the day-to-day operations of the Finance department including the management of the month-end close process, accounts payable operations, payroll, and bank reconciliations.  The role will assist with other activities, such as budgeting and financial analysis, to support the company growth, as well as providing select, confidential administrative work with the Human Resources department.  The position requires professionalism and discretion, the ability to multi-task while delivering high quality work, and the capability to work effectively in a rapidly changing environment.  The role will interact closely with all levels of management and staff, as well as outside service providers (vendors, consultants, attorneys, etc.).  To succeed at X4, the candidate will have a sustained reputation for a values-driven, collaborative, engagement style where integrity and the consideration of our Patients drives all decisions and actions.

Scope of Work and Responsibilities:

  • Manage all day-to-day accounts payable operations, including vendor management, invoice entry, and payment and provide suggestions for continued improvement for all processes and efficiencies
  • Develop process for purchase orders to support work orders and compliant invoice and purchase order approval process
  • Manage the Company’s corporate credit cards and related monthly reconciliation
  • Manage the year-end audit process including managing materials to support audit requirements/requests and interacting with auditors
  • Ensure review, timely processing, and payment of compliant expense reports
  • Manage the monthly close and financial reporting processes
  • Preparation of monthly bank reconciliations to ensure accuracy and timeliness
  • Manage the complete payroll process, including regular and special payrolls, all timely changes to payroll, and reconciling payroll to the general ledger
  • Work closely with Human Resources to ensure timely and accurate employee transactions and to provide ad hoc confidential support (PTO tracking, benefits administration, etc.)
  • Work closely with the Clinical Operations team, identify cost drivers, and provide support for the cost projections and accruals of clinical trials
  • Assist in the preparation of budgets, forecasts, and financial analysis
  • Support compliance across the company including tax filings, implementation of controls, and governance
  • Create and update policies and process documents as needed
  • Support potential system implementations and upgrades including ERP, HRIS, or Payroll
  • Special projects and other tasks as assigned

Qualifications and Professional Skills:

  • Bachelor’s degree in Accounting or Finance, CPA preferred
  • 3-5 years of experience, public accounting and/or life science/biotech preferred
  • Understanding of Sarbanes-Oxley (“SOX”) documentation and requirements
  • Broad knowledge of accounting principles (“GAAP”)
  • Strong expertise with ERP systems and advanced skill and experience in Excel
  • Experience using payroll systems, ADP preferred
  • Outstanding verbal, written and technology communication skills successfully working with all levels of the organization; high proficiency with Microsoft Office suite (PowerPoint, Excel, and Word)
  • Experience with budgeting, forecasting, and financial analysis
  • Proven effectiveness in time management, attention to detail and organizational skills
  • Reputation for successfully building sustained, external third-party relationships while representing the best interests of the Company
  • Proven history keeping sensitive information confidential

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. 

Qualified candidates please apply to careers@x4pharma.com

Vice President, Clinical Operations

Company Description:

X4 Pharmaceuticals is developing novel therapeutics designed to improve immune cell trafficking including the ability for T-cells to track and destroy cancer cells. Our small molecule drug candidates inhibit C-X-C receptor type 4 (CXCR4), a receptor over-expressed in many cancers. Inhibition of CXCR4 is designed to block non-cancerous immunosuppressive and pro-angiogenic cells from populating the tumor, disrupting the cancer microenvironment and restoring normal immune surveillance functions. We are committed to advancing the field of cancer immunotherapy and immune disorders through innovation and investment in our proprietary clinical and preclinical pipeline.

Reporting to the Chief Medical Officer, the Vice President, Clinical Operations is an experienced leader with a focus on strategic planning and execution of clinical trials to gain regulatory approval of current and future X4 programs. The incumbent will have a proven track record of leading and planning to ensure that program goals are met timely, efficiently, and on budget. This position requires someone that is a self-starter and can act in different roles within this position to support the mission of X4. This position also includes direct staff management, training and development; serving as a leader of the company with impactful involvement on leadership decisions, meetings, etc. This position requires a well-rounded individual to lead in various areas of Clinical Operations that can provide insight, advisement, and clarity into various day-to-day Clinical Operations tasks.

A proven leader of people and process with an uncompromised commitment to the Patient.

Scope of Work and Responsibilities:

  • Lead Cinical Operations, Data Management, Biostatistics and Medical Writing internal functions or with external service providers
  • Assist in the strategic development and execution of various clinical trials, ensures timeliness and budgets are achieved
  • Creates and manages to clinical budgets
  • Lead the selection and evaluation and effectiveness of CROs, sets standards for evaluation of CROs and reviews regularly
  • Interacts with external vendors and clients such as investigator sites, CROs, CRAs, and other vendors
  • Responsible for ensuring efficient and effective study formulation and implementation
  • Coordinates data analysis and ensures accuracy and timeliness
  • Interacts with the FDA and other global regulatory agencies
  • Certifies continuous compliance in clinical trials
  • Reviews and edits study protocols, outlines, amendments, and Investigator brochures

Qualifications and Professional Skills:

  • Bachelor’s degree in related field
  • 10+ years of relevant Clinical Operations experience in Biotech/Biopharma
  • Experience with IND and NDA submissions
  • Familiar and comfortable with clinical operations concepts and operational practices and needs
  • History of successful management and interaction and on-going process improvement with CROs, vendors, and other external partners
  • Proven team member that can work independently and collaboratively
  • Detail oriented and able to guide Clinical Operations improvements in a rapidly changing climate growing companyExperience in FDA regulations, other international regulatory agencies
  • Prior experience successfully managing and developing direct report(s)
  • Proven track record of managing multiple projects and/or programs concurrently
  • Self-starter with a positive work ethic

The above statements are intended to describe the general nature and level of work being performed.  They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce.  All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.   Please send your resume and cover letter to careers@x4pharma.com

We invite you to apply for any of our current openings at careers@x4pharma.com for additional employment related information.