Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision
  • Say what they mean, and let their words match their actions
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

Open Positions

Location: Boston MA, USA

Senior Clinical Data Manager

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in Phase 3 development for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof of concept in WHIM in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. A Phase 2 open label extension study for WHIM is ongoing. Mavorixafor was designated orphan drug status by the U.S. Food and Drug Administration in 2018 for the treatment of WHIM and is also in development for Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4 is also developing X4P-002, a CXCR4 antagonist that has unique properties that the company believes will enable penetration of the blood-brain barrier and provide appropriate therapeutic exposures to treat brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Senior Director, Biometrics the Senior Clinical Data Manager will be responsible for all clinical data activities across X4’s innovative portfolio. He/She will be proficient in various tools to collect, clean-up, review, and report the data in a timely and accurate fashion. Additionally, the Clinical Data Manager will manage global CROs and will act as an internal expert in all areas of CDM processes and technology.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

 

Scope of Work and Accountabilities:

  • Drive and lead the development of all database and eCRF design
  • Plan, develop and implement UAT (user acceptance testing), data specifications, data entry guidelines, CRF completion guidelines, and related operational manuals/guidelines
  • Develop and execute data validation guidelines and measures to ensure accurate data gathering from clinical studies
  • Review and provide expertise on all eCRF changes, respond accordingly to make resulting database changes
  • Organize and direct the initial stage of the studies, review and sign off on various items such as eCRF, data validation, data review guidelines, and data management plans
  • Collaborate and build strong sustainable relationships with multiple global CROs along with managing the process and coordination of each
  • Accountable for ensuring all data quality and timeliness of CDM deliverables are met and aligned with the business goals
  • Review, track and report status of all data management project(s) to senior leadership
  • Responsible for managing the clinical trial data queries along with the planning and execution of medical coding and SAE reconciliation
  • Maintain data integrity in compliance with GCP, relevant SOPs and regulatory requirements by reviewing data processes and filing documentation in the trial master file (TMF)
  • Develop strong partnerships with cross functional key stake holders to meet project deliverables and timelines for clinical data acquisition, quality checking and reporting
  • Formulate and develop data management SOPs and processes that align and address business priorities
  • Reputation for data integrity and compliance

 

Qualifications and Professional Experience:

  • Bachelor’s degree required within a scientific discipline, advanced degree a plus
  • Minimum eight years of experience within biotech/biopharma and/or CRO organization
  • Extensive knowledge and experience in clinical data management
  • Direct experience with different Data Management systems and technologies, Electronic Data Capture systems and CDISC data standards
  • Extensive knowledge reviewing study planning documents such as Edit Check Specs, UAT scripts, Data Management Plans
  • Comprehensive understanding of database and dictionary structures (e.g., MedDRA, WHO DRUG)
  • Deep understanding of drug development, study conduct processes, GCP and regulations related clinical data management as well as ICH guidelines, FDA/EU regulations

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Payroll and Equity Manager

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, oncedaily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Comission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Senior Manager, Accounting, the Payroll and Equity Manager will have responsibility for the payroll process as well as equity administration. The position requires professionalism and discretion, the ability to multi-task while delivering high quality work, and the capability to work effectively in a rapidly changing environment. He/She will interact closely with all levels of management and staff, as well as outside service providers (vendors, consultants, attorneys, etc.). To succeed at X4, he/she will have a sustained reputation for a values-driven, collaborative, engagement style where integrity and the consideration of our Patients drives all decisions and actions.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

 

Scope of Work and Accountabilities:

Payroll

  • Manage the timely and accurate payroll process, including regular and special payrolls, approved changes to payroll, and the reconciliation of the payroll to the general ledger
  • Prepare journal entries and account reconciliations for all payroll related accounts
  • Respond to confidential questions from employees regarding paychecks, direct deposits, tax deductions, and/or general payroll questions.
  • Assist in the quarterly and year-end audit process including managing materials to support audit requirements/requests and interactions with auditors
  • Partner closely with Human Resources to ensure timely and accurate employee transactions and to provide ad hoc confidential support (PTO tracking, benefits administration, etc.)
  • Create and update policies and process documents, as needed
  • Support potential system implementations and upgrades including ERP, HRIS, or Payroll
  • Special projects and other tasks as assigned

Equity

  • Own the Equity Administration process, including timely and accurate coordination of award approvals, monitoring share pool reserves and processing stock award grants, exercises and vesting events
  • Assist with the period end financing reporting associated with our equity plans, including calculation of the fair value of equity awards and preparation of period end journal entries
  • Establish new hires in our equity administration system (Shareworks by Morgan Stanley, formerly Solium)
  • Reconcile equity award activity between Shareworks and our transfer agent records
  • Respond to questions from employees and others related to equity awards
  • Support communication and compliance with our insider trading policies, including monitoring 10b5-1 plans
  • File required forms with the Securities and Exchange Commission related to executive-level purchases and sales of our common stock
  • Support potential system implementations and upgrades including ERP, HRIS, or Payroll
  • Special projects and other tasks as assigned

 

Qualifications and Professional Experience:

  • Bachelor’s degree in Accounting or Finance
  • 7+ years of experience in payroll
  • Experience with equity plan administration
  • Understanding of internal controls (including Sarbanes-Oxley documentation) related to payroll and equity
  • Basic knowledge of accounting principles (“GAAP”)
  • Strong expertise with ERP systems and advanced skill and experience in Excel
  • Experience using payroll (ADP preferred) and equity administration systems
  • Outstanding verbal, written and technology communication skills successfully working with all levels of the organization; high proficiency with Microsoft Office suite (PowerPoint, Excel, and Word)
  • Proven history keeping sensitive information confidential
  • Reputation for integrity, high quality work and commitment to compliance

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Director/Senior Director, Clinical Business Operations

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Head of Development Operations, the Director/Senior Director, Clinical Business Operations will be responsible for building and leading Clinical Business Operations capabilities to optimize Clinical Operations’ performance, costs and quality. He/She will partner closely with Quality Assurance to ensure Clinical Operations’ GCP compliance, completion of SOPs and audit readiness. The candidate will lead initiatives to improve effectiveness and efficiency within Clinical Operations as well as in outsourcing including RFP and bid defense process. He/She will also assess current capabilities, identify gaps / opportunities to enable the advancement of the pipeline and function as the driver of, and process champion for, new capability builds. In addition, the candidate will have oversight of all SOP and Training, Process and Inspection Readiness, Trial Master File, and the Systems and Metrics teams.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

 

Scope of Work and Accountabilities:

  • Create, define and lead the overall outsourcing strategy, including potential preferred provider relationships, negotiated rates, volume discounts, etc.
  • Partner with the key business stakeholders across the organization to define and execute sourcing strategy to meet X4’s long-term business objectives.
  • Drive company-wide compliance of outsourcing procedures and look to improve processes and policies to drive highly effective and efficient processing and reporting on purchased goods and services.
  • Operationalize category management to deliver value across the organization through cross-functional project execution, operational excellence, supplier relationship management, negotiation of supply agreements, performance measurement and risk management.
  • Collaborate with internal business partners and advocate for strong account and vendor management capabilities within X4 business lines.
  • Map and evaluate X4 vendor landscape to improve vendor performance, gain efficiencies, and reduce risk while identifying opportunities for cost savings and track category spend and ROI
  • Identify, lead and execute operational excellence strategy.
  • Lead the implementation/evolution of Clinical Operations systems, processes and ensure alignment on standard practices across functions or teams.
  • Establish and foster effective executive relationships with key suppliers
  • Identify opportunities to leverage within and across vendors; build strong partnerships to enable streamlined outsourcing approach
  • Support the clinical development team(s) in leading the RFI/RFPs/bid defense process for vendor selection
  • Support root-cause analyses and remediation CAPAs for cross-functional quality and execution challenges in partnership with the Head of Development Operations
  • Assess, support and select/implement tools and technologies to meet Clinical Operations business needs
  • Represent Clinical Operations in cross-functional project workstream(s) to successfully implement new processes and quality improvement activities for operational efficiency
  • Partner with Head of Development Operations in the development of project updates, reports, memos, and presentations, as needed
  • Support Head of Development Operations in management of budget, capacity, resources and preparation of associated analyses and reports
  • Proactively identify risks and issues that could impact the successful execution of business objectives and support the development of appropriate mitigation or corrective action plans for vendor performance or quality issues
  • Support root-cause analyses and remediation CAPAs for cross-functional quality and execution challenges in partnership with the Head of Development Operations
  • Develop milestone timeline dashboards and KPIs
  • Oversee vendor governance activities and coordinate oversight meetings
  • Partner with Clinical Operations, Finance and Legal to create standard vendor budget and SOW templates

 

Qualifications and Professional Experience:

  • Advanced scientific degree with at least 13 years of work experience in the Pharmaceutical/Biotechnology industry
  • Deep knowledge and experience in Clinical Business Operations, Clinical Operations leadership and/or outsourcing oversight and relationship management
  • Expert knowledge of FDA and ICH GCP regulations and guidelines
  • Experience in the clinical drug development process within clinical program planning through final study report
  • Excellent people leader with strong coaching and mentoring skills
  • Track record of strong personal performance combined with demonstrated ability to build and lead high performing teams in a fast growth environment
  • Demonstrated problem-solving and critical thinking skills
  • Demonstrated ability to work effectively in a dynamic, complex and fast-paced team environment

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

We invite you to apply for any of our current openings at careers@x4pharma.com for additional employment related information.

Location: Vienna, Austria

Privacy Notice for applications of X4 Pharmaceuticals (Austria) GmbH in accordance with Article 13 of the General Data Protection Regulation (“GDPR”)

We invite you to apply for any of our current openings at careers-vienna@x4pharma.com for additional employment related information.

 

X4 Pharmaceuticals does not review or control the content on the website to which this hyperlink connects and this hyperlink does not constitute an endorsement by X4 Pharmaceuticals of the content of any non-X4 Pharmaceuticals website.

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