Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision
  • Say what they mean, and let their words match their actions
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

Open Positions

Location: Boston MA, USA

Senior Clinical Data Manager

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in Phase 3 development for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof of concept in WHIM in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. A Phase 2 open label extension study for WHIM is ongoing. Mavorixafor was designated orphan drug status by the U.S. Food and Drug Administration in 2018 for the treatment of WHIM and is also in development for Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4 is also developing X4P-002, a CXCR4 antagonist that has unique properties that the company believes will enable penetration of the blood-brain barrier and provide appropriate therapeutic exposures to treat brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Senior Director, Biometrics the Senior Clinical Data Manager will be responsible for all clinical data activities across X4’s innovative portfolio. He/She will be proficient in various tools to collect, clean-up, review, and report the data in a timely and accurate fashion. Additionally, the Clinical Data Manager will manage global CROs and will act as an internal expert in all areas of CDM processes and technology.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

 

Scope of Work and Accountabilities:

  • Drive and lead the development of all database and eCRF design
  • Plan, develop and implement UAT (user acceptance testing), data specifications, data entry guidelines, CRF completion guidelines, and related operational manuals/guidelines
  • Develop and execute data validation guidelines and measures to ensure accurate data gathering from clinical studies
  • Review and provide expertise on all eCRF changes, respond accordingly to make resulting database changes
  • Organize and direct the initial stage of the studies, review and sign off on various items such as eCRF, data validation, data review guidelines, and data management plans
  • Collaborate and build strong sustainable relationships with multiple global CROs along with managing the process and coordination of each
  • Accountable for ensuring all data quality and timeliness of CDM deliverables are met and aligned with the business goals
  • Review, track and report status of all data management project(s) to senior leadership
  • Responsible for managing the clinical trial data queries along with the planning and execution of medical coding and SAE reconciliation
  • Maintain data integrity in compliance with GCP, relevant SOPs and regulatory requirements by reviewing data processes and filing documentation in the trial master file (TMF)
  • Develop strong partnerships with cross functional key stake holders to meet project deliverables and timelines for clinical data acquisition, quality checking and reporting
  • Formulate and develop data management SOPs and processes that align and address business priorities
  • Reputation for data integrity and compliance

 

Qualifications and Professional Experience:

  • Bachelor’s degree required within a scientific discipline, advanced degree a plus
  • Minimum eight years of experience within biotech/biopharma and/or CRO organization
  • Extensive knowledge and experience in clinical data management
  • Direct experience with different Data Management systems and technologies, Electronic Data Capture systems and CDISC data standards
  • Extensive knowledge reviewing study planning documents such as Edit Check Specs, UAT scripts, Data Management Plans
  • Comprehensive understanding of database and dictionary structures (e.g., MedDRA, WHO DRUG)
  • Deep understanding of drug development, study conduct processes, GCP and regulations related clinical data management as well as ICH guidelines, FDA/EU regulations

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Director, Regulatory Affairs

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, oncedaily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Comission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Senior Director, Regulatory Affairs, the Director, Regulatory Affairs will be responsible for overseeing the global regulatory strategic plans for the development of current and future indications. He/She must possess excellent judgment, organizational and planning skills along with exceptional written and verbal communications. The successful candidate will also influence and negotiate professionally at various levels within the project team and with external partners while maintaining positive working relationships. This position works with a high level of independence and autonomy, has a high degree of latitude to manage workload, takes initiative and defines direction without needing guidance. He/She will act as a subject matter expert in a matrix team environment and motivates self and others to complete projects on time. The candidate works often with a moderate level of ambiguity and complex problems focusing on developing and coordinating the implementation of a global regulatory strategy.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

 

Scope of Work and Accountabilities:

  • Lead and drive the preparation, alignment, formulation, communication, and implementation of global regulatory registration strategies with direct accountability for US, Europe and other geographies, as needed, while adhering to corporate objectives.
  • With oversight from the Senior Director, acts as single point of contact to FDA and other regulatory authorities for products/projects. Liaises, negotiates and leads FDA and/or EMA interactions, including required documentation of the interaction, decisions and outcomes.
  • Independently leads the preparation, coordination or monitoring of regulatory submissions. Interacts across the organization to obtain and/or provide information/data for regulatory submissions.
  • Develops and builds strong relationships with Regulatory Affairs team members, FDA Project Managers and/or Reviewers, and may interact directly or indirectly with ex-US Health Authorities.
  • Provides regulatory affairs representation on project teams and will be expected to lead regulatory sub-teams. May act as single point of Regulatory Affairs contact on cross-functional teams and ensure all information is aligned throughout the organization.
  • Accountable for providing timely dissemination of regulatory intelligence, as appropriate to continually educate and inform project team(s).
  • Maintains a high level of regulatory knowledge and provides regulatory advice to program teams, internal and external partners on development assets and the broader organization.
  • Provides forward thinking insights and risk assessment to inform leadership decisions.

 

Qualifications and Professional Experience:

  • Bachelor’s degree required; advanced degree preferred
  • A minimum of 10 years in the biotechnology and/or biopharmaceutical industry
  • Minimum seven years in a Regulatory capacity with experience in several therapeutic areas, preferably in biotech and biopharma through commercialization. Experience in Rare Disease is highly valuable.
  • Preferred candidates will have experience working as a lead in Regulatory Affairs across two or more major geographic areas and prior experience with both small molecules and biologics
  • Proven experience as a respected leader of high performing talent
  • Expert in global regulatory guidelines required to lead the overall regulatory strategy
  • Demonstrated experience interacting with the Food and Drug Administration (FDA), European Medicines Agency (EMA), and other regulatory agencies
  • Proven leadership experience in the establishment and submission of INDs and approvals of NDAs and BLAs
  • Known reputation for integrity professionalism with colleagues and external Partners.
  • Expertise in the all phases of drug development including Regulatory experience implementing the life cycle of a product from Phase III to commercialization in several therapeutic areas.

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Payroll and Equity Manager

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, oncedaily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Comission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Senior Manager, Accounting, the Payroll and Equity Manager will have responsibility for the payroll process as well as equity administration. The position requires professionalism and discretion, the ability to multi-task while delivering high quality work, and the capability to work effectively in a rapidly changing environment. He/She will interact closely with all levels of management and staff, as well as outside service providers (vendors, consultants, attorneys, etc.). To succeed at X4, he/she will have a sustained reputation for a values-driven, collaborative, engagement style where integrity and the consideration of our Patients drives all decisions and actions.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

 

Scope of Work and Accountabilities:

Payroll

  • Manage the timely and accurate payroll process, including regular and special payrolls, approved changes to payroll, and the reconciliation of the payroll to the general ledger
  • Prepare journal entries and account reconciliations for all payroll related accounts
  • Respond to confidential questions from employees regarding paychecks, direct deposits, tax deductions, and/or general payroll questions.
  • Assist in the quarterly and year-end audit process including managing materials to support audit requirements/requests and interactions with auditors
  • Partner closely with Human Resources to ensure timely and accurate employee transactions and to provide ad hoc confidential support (PTO tracking, benefits administration, etc.)
  • Create and update policies and process documents, as needed
  • Support potential system implementations and upgrades including ERP, HRIS, or Payroll
  • Special projects and other tasks as assigned

Equity

  • Own the Equity Administration process, including timely and accurate coordination of award approvals, monitoring share pool reserves and processing stock award grants, exercises and vesting events
  • Assist with the period end financing reporting associated with our equity plans, including calculation of the fair value of equity awards and preparation of period end journal entries
  • Establish new hires in our equity administration system (Shareworks by Morgan Stanley, formerly Solium)
  • Reconcile equity award activity between Shareworks and our transfer agent records
  • Respond to questions from employees and others related to equity awards
  • Support communication and compliance with our insider trading policies, including monitoring 10b5-1 plans
  • File required forms with the Securities and Exchange Commission related to executive-level purchases and sales of our common stock
  • Support potential system implementations and upgrades including ERP, HRIS, or Payroll
  • Special projects and other tasks as assigned

 

Qualifications and Professional Experience:

  • Bachelor’s degree in Accounting or Finance
  • 7+ years of experience in payroll
  • Experience with equity plan administration
  • Understanding of internal controls (including Sarbanes-Oxley documentation) related to payroll and equity
  • Basic knowledge of accounting principles (“GAAP”)
  • Strong expertise with ERP systems and advanced skill and experience in Excel
  • Experience using payroll (ADP preferred) and equity administration systems
  • Outstanding verbal, written and technology communication skills successfully working with all levels of the organization; high proficiency with Microsoft Office suite (PowerPoint, Excel, and Word)
  • Proven history keeping sensitive information confidential
  • Reputation for integrity, high quality work and commitment to compliance

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

We invite you to apply for any of our current openings at careers@x4pharma.com for additional employment related information.

Location: Vienna, Austria

Privacy Notice for applications of X4 Pharmaceuticals (Austria) GmbH in accordance with Article 13 of the General Data Protection Regulation (“GDPR”)
Technician – Discovery Department (located in Vienna, Austria)

About X4 Pharmaceuticals

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, Mavorixafor (X4P-001), is a once daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Comission in 2019 for the treatment of WHIM syndrome.

Mavorixador is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on Campus Vienna Biocenter and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics.

X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Technician – Discovery Department.

 

Summary of the position:

The Technician – Discovery Department will participate in developing in vitro models of primary immune deficiencies and rare cancers, with a focus on genotype-phenotype correlation.

 

Scope of work:

  • Mammalian cell culture
  • Routine molecular biology techniques (PCR, cloning)
  • Generation of stable cell lines
  • Flow cytometry, ELISA, WB, microscopy
  • Cell based assays (migration, differentiation)
  • General lab support

 

Qualifications and skills:

  • Bachelor, Master, or PhD degree (or equivalent) with strong wet-lab experience
  • Extensive experience with mammalian cell culture, transfections, cell-based ELISA, flow cytometry and WB
  • Ability to draft routine reports and keep accurate records of work performed
  • High accuracy, reliability, precision under time pressure
  • Organizational skills and flexible mind-set
  • Previous work with iPSCs (preferred but not required)
  • Experience with hematopoietic cell culture (preferred but not required)

 

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegiate working environment
  • Opportunities for your personal development and to play a key role in a growing international research center

 

In accordance with Austrian employment law, the minimum monthly gross salary for the position is EUR 2,740.27 which we are willing to adjust according to your qualifications, skills and expertise.

Please send your resume and cover letter in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

Scientist – Discovery Department (located in Vienna, Austria)

About X4 Pharmaceuticals

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, Mavorixafor (X4P-001), is a once daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Comission in 2019 for the treatment of WHIM syndrome.

Mavorixador is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on Campus Vienna Biocenter and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics.

X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Scientist – Discovery Department.

 

Summary of the position:

The Scientist – Discovery Department will contribute to the identification, validation and characterization of novel PID targets and therapeutics, with a focus on WHIM and severe congenital neutropenia.

 

Scope of work:

  • Identify new target gene/pathway candidates based on genetic screening and patient population data
  • Explore the genotype/phenotype correlation using recombinant cell systems and patient samples
  • Design, implement and develop in vitro and ex vivo assays for functional and pharmacological target validation
  • Develop high-throughput assays for hit identification
  • Perform detailed mode of action studies to guide lead selection
  • Present data at internal and external meetings
  • Write reports and scientific publications

 

Qualifications and skills:

  • PhD in Immunology, Cell Biology, or Bioinformatics with at least two years of post-doctoral experience or corresponding industrial experience
  • Scientific rigor and strong analytical skills
  • Good understanding of immune disease pathways, immune cell biology and infection biology
  • Strong hands/on experience with genetic manipulation, mammalian cell culture and phenotypic studies
  • Familiarity with bioinformatics workflows
  • Experience with confocal microscopy, iPSC handling, FACS and/or genetic data mining is beneficial
  • Ability to supervise and train laboratory staff

 

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegial working environment
  • Opportunities for your personal development and to play a key role in a growing international research center
  • Opportunity to work at the interface of pre-clinical research and clinical translational science

 

In accordance with Austrian employment law, the minimum monthly gross salary for the position is
EUR 3.428,19 which we are willing to adjust according to your qualifications, skills and expertise.

Please send your resume and cover letter in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

We invite you to apply for any of our current openings at careers-vienna@x4pharma.com for additional employment related information.

 

X4 Pharmaceuticals does not review or control the content on the website to which this hyperlink connects and this hyperlink does not constitute an endorsement by X4 Pharmaceuticals of the content of any non-X4 Pharmaceuticals website.

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