Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision
  • Say what they mean, and let their words match their actions
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

Open Positions

Location: Boston MA, USA

Director, Manufacturing and Supply Chain Quality

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in Phase 3 development for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof of concept in WHIM in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. A Phase 2 open label extension study for WHIM is ongoing. Mavorixafor was designated orphan drug status by the U.S. Food and Drug Administration in 2018 for the treatment of WHIM and is also in development for Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4 is also developing X4P-002, a CXCR4 antagonist that has unique properties that the company believes will enable penetration of the blood-brain barrier and provide appropriate therapeutic exposures to treat brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Vice President, Quality, the Director Manufacturing and Supply Chain Quality will lead and drive the GMP Quality Operations related activities at X4 Pharma. This role will represent Quality on CMC teams for all X4 programs, will partner internally with Quality Systems, Analytical Development, Process and Product Development, CMC Leadership and Supply Chain functions to ensure clinical supply, support commercialization of X4 products and to develop and implement phase appropriate quality systems, and foster strong relationships with external partners to build a quality focused, efficient and collaborative culture to meet department and company goals.

The incumbent will ensure high quality execution of manufacturing and supply chain operations for clinical products and establish readiness for commercial marketing authorization and launch. The role requires to champion and drive multiple workstreams.

This position is located in Allston, MA and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

 

Scope of Work and Accountabilities:

  • Lead the Manufacturing and Supply Chain Quality function within the Quality department to meet organizational goals and objectives
  • Participate in the effective quality oversight of cGMP activities at X4 and its external manufacturing and testing partners for clinical stage products
  • Shape and drive Quality culture, fostering a proactive, phase appropriate quality focused approach
  • Improve existing and develop/implement new GMP processes in partnership with Quality Systems and Technical Operations for product commercialization in compliance with applicable regulation
  • Partner and provide oversight and guidance on GMP compliance matters within CMC teams
  • Develop, implement and execute a risk-based audit strategy for GMP Vendors
  • Lead and manage GMP audits including oversight of consultant mediated and/or self-conducted Vendor Qualification audits
  • Assist and advise in the development of CAPA plans in response to audits/inspections and review and follow-up of all audit CAPAs
  • Establish and maintain Quality Agreements with Vendors
  • Ensure products for human use are manufactured in compliance with the applicable requirements, regulations and guidance and meet appropriate quality specifications and standards
  • Provide day-to-day quality and compliance support, including issue management (triage/investigation/actions), batch record review, lot disposition, change controls etc.
  • Provide and drive training sessions and mentor top performing teams on topics related to GMP quality and global regulations
  • Partner with key internal and external partners to champion prospective Inspection Readiness
  • Periodically report the state of GMP Quality and compliance to X4 Senior Management
  • Establish a strong interface with the external development and manufacturing partners while building strong relationships and fostering continuous improvement
  • Support all product development and commercialization related activities, including process performance qualification, submission of regulatory filings, and product launch

 

Qualifications and Professional Experience:

  • BS or MS in engineering or life sciences technical discipline
  • Minimum 12 years of relevant industry experience in Quality Assurance, including management of virtual manufacturing and distribution supply chain
  • Experience with rare disease products is a plus
  • Knowledge and understanding of ICH Guidelines, and FDA and EU Requirements
  • In-depth knowledge and understanding of Data Integrity requirements
  • Direct experience in managing Health Authority GMP Inspections is highly preferred.
  • Proven experience with developing strong partnerships with cross functional senior key stakeholders to ensure that strategic business goals are met through the sharing of knowledge and teamwork
  • Demonstrated experience with content ownership, delivery and strategic thinking
  • Proven effective time management skills, ability to work independently and in a team environment that drives business needs forward
  • Must be willing to travel domestically and internationally up to 25%

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Senior Director / Vice President, Corporate Communications & Investor Relations

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Chief Financial Officer, the Senior Director / Vice President, Corporate Communications & Investor Relations will be responsible for strategic and operational leadership of all company communications. He/She will lead our external investor strategies and manage our external and internal communications, ensuring consistent messaging across all platforms to all stakeholders, both internal and external. He/She will also lead the development, implementation, and management of a comprehensive investor relations and corporate communications strategy and manage relationships with the investment community, including investors and sell-side analysts. This individual will also be responsible for all corporate communications, including corporate visibility, media and public relations, alignment with corporate strategy and public affairs. Other aspects of the position will include contributing to the company’s branding, employer branding and internal messaging strategy and execution. This position will require developing a strong business relationship and collaborating with the executive team, along with all internal functional leads as well as human resources.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

 

Scope of Work and Accountabilities:

  • Lead and implement the strategic planning, direction, and execution of all Investor Relations, Public Relations, and Corporate Communications for the organization
  • Develop, oversee, and drive a strategic and comprehensive investor relations plan to align with the overall business objectives.
  • Partner with the CEO and CFO to lead and manage the company’s participation on quarterly earnings calls, investment conference calls and in-house meetings, roadshows, analyst days, and one-on-one meetings.
  • Develop and lead all strategic communications including, developing communication plans to take advantage of key company milestones, preparing press releases, presentation decks, and earnings releases. Creating management Q&As, conference call scripts, and business descriptions/other information for securities filings, the annual report, and the company website
  • Interact across the organization to target, surface, and generate awareness around potential news flow and monitor/manage via a knowledge map document and related internal communications meetings.
  • Coordinate, plan and execute key company events, including analyst days, medical conferences, data presentations and other related news-driven opportunities.
  • Build strong relationships and maintain regular communication with individual investors. Select sell-side contacts to provide up-to-date information about events and market trends affecting the company to communicate our long-term vision.
  • Collaborate and coordinate with other functional areas to develop messaging that authentically promotes the company internally and externally.
  • In partnership with Human Resources, functional leads, general counsel, and corporate counsel, manage internal employee communications and media training, including managing town halls and certain internal company meetings.
  • Develop and evolve the communication strategy to align with changes to the business.
  • Confirm and verify all information is following product promotion guidelines, SEC regulations and adheres to Regulation Fair Disclosure
  • Lead and develop strong partnerships with all external firms and consultants, including digital /social media firms, to ensure projects are delivered on time and within budget.

 

Qualifications and Professional Experience:

  • 10+ years in the biotech /pharmaceutical industry, with direct experience leading investor relations and corporate communications within a publicly traded biotech company
  • Bachelor’s degree required; Master’s degree preferred in a related discipline.
  • Reputation for successful business interactions, established relationships and credibility with the investment community, media, and biopharma journalists.
  • Ability to maintain confidentiality, exercise sound judgment and the highest level of discretion; knowledge of SEC and disclosure requirements preferred.
  • Exceptionally strong verbal, written and digital communication skills, including the robust ability to present clearly and concisely both scientifically and technically to various audiences.
  • Deep knowledge and experience with managing and overseeing contract IR/PR agencies and vendors.
  • Proven experience with developing strong partnerships with cross-functional senior key stakeholders to ensure that strategic business goals are met through the sharing of knowledge and teamwork.

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Senior Director, Information Technology

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Vice President, Finance & Corporate Controller, the Senior Director, Information Technology will oversee all aspects of information technology, including strategy, operations, security, governance, and policies and risk assessment. He/she will be expected to develop an information technology and security vision/strategy that will support and align with the organizational priorities. Furthermore, support business capabilities that ensure technology architecture and governance align with strategic business initiatives. He/she will be a strong, motivated leader who has demonstrated success driving business transformation within a fast-paced, publicly traded organization.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

 

Scope of Work and Accountabilities:

  • Develop and implement a strategic roadmap for IT, including network infrastructure, computing hardware, business software, cyber and data security.
  • Oversee all technology operations and evaluate them according to the overall corporate growth plans.
  • Lead and develop IT financial budgets and forecasts to ensure IT projects are delivered on time and within budget.
  • Drive disciplined investment decisions, including using total cost of ownership and return on investment analysis to help prioritize the portfolio of projects.
  • Build and manage a team of IT professionals and vendors to execute projects and provide daily IT operations support to the business as it prepares for commercialization.
  • Evaluate and determine a balance between insourced and outsourced IT service models.
  • Oversee security awareness training program for all employees, contractors, and approved system users, and establish metrics to measure the effectiveness of this security training program for the different audiences.
  • Identify and interact with functional areas to ensure the consistent application of policies and standards across all technology projects, systems, and services, including privacy, risk management, compliance, and business continuity management.
  • Establish and support IT general controls and ensure compliance with industry best practices, SOX, Part 11, and other relevant regulatory requirements.
  • Provide clear risk mitigating directives for projects with components in IT, including the mandatory application of controls.
  • Lead the information security function across the company to ensure consistent and high-quality information security management to support the business goals.
  • Oversight of GDPR compliance, Cybersecurity procedures, business continuity, disaster recovery, IT change management/controls, and IT policy and procedures.

 

Qualifications and Professional Experience:

  • Bachelor’s degree in Computer Science or Related Field
  • 10+ years of experience, including management experience, in a fast-paced organization, preferably within a commercial Biotech/Biopharmaceutical company
  • Experience in a publicly traded company required.
  • Deep knowledge and expertise in project management with a proven track record to plan, execute and deliver projects on time and within budget.
  • Ability to exercise discretion in handling confidential material and information.
  • Proven experience with developing resilient internal/external partnerships to ensure that strategic business goals are met through the sharing of knowledge and teamwork.
  • Ability to manage multiple activities simultaneously and prioritize effectively.
  • In-depth experience managing SOX-compliant technology environments and systems preferred.
  • Demonstrated ability to manage business systems software projects, including defining, planning, and executing predictable schedules, cost estimates, and required quality.
  • Deep knowledge and understanding of selection, deployment, and management of business tools such as ERP, CRM, and other systems.
  • Well-respected reputation for integrity, discretion, and sound judgment

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

We invite you to apply for any of our current openings at careers@x4pharma.com for additional employment related information.

Location: Vienna, Austria

Privacy Notice for applications of X4 Pharmaceuticals (Austria) GmbH in accordance with Article 13 of the General Data Protection Regulation (“GDPR”)
Scientist – Translational Sciences

About X4 Pharmaceuticals: 

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on the Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Scientist – Translational Sciences.

 

Summary of the position:

We are looking for an experienced and highly motivated Scientist – Translational Sciences with a strong background in translational research and discovery including pharmacological and disease animal models as well as assays with clinical/human specimens for the mechanistic characterization of new therapies. The successful candidate will contribute to the identification, validation and characterization of novel targets and therapeutics, with a focus on primary immunodeficiencies and cancers as well as new indications including neurodegeneration. Reporting to the Senior Director, Translational Sciences, the main duties will include:

  • Work with an established team of Research Associates within the Translational Sciences Department
  • Collaborate with internal and external research teams and CROs to advance our translational research capabilities
  • Contribute to the identification and validation as well as project development processes for new therapeutic targets and indications
  • Select and perform pharmacological and efficacy studies in relevant animal models within a variety of therapeutic areas
  • Develop and execute on in vitro assays including biomarker studies to support clinical trials and mode-of-action studies of our compounds
  • Analyze and present data at internal and external meetings
  • Write reports and scientific publications

Qualifications and skills:

  • PhD degree in relevant field (e.g. B and T cell immunology, oncology, hematology, neurobiology or cell biology)
  • Minimum of four years of post-doctoral and wet lab experience or corresponding industrial experience
  • Expertise in pharmacology and disease animal models
  • Strength in research and interpretation of large datasets and cross-functional studies in various disease indications
  • Extensive experience and trouble-shooting skills in relevant molecular biology techniques
  • Experience working within a Biosafety Level 2 laboratory including work with bacterial/viral pathogens and patient material as well as analysis and interpretation of sophisticated sequencing methods (e.g. scRNAseq), transcriptomics and/or proteomics in an advantage
  • Effective communication and relationship building skills with internal and external stakeholders
  • Independent, proactive, and hands-on team player with strategic thinking and sense of urgency
  • Ability to supervise and train laboratory staff

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegial working environment
  • Opportunities for your personal and career development and to play a key role in a growing international research center
  • Opportunity to work at the interface of pre-clinical research and clinical translational science

 

In accordance with Austrian employment law, the minimum gross salary p.a. for the position is EUR 48.690,60 which we will adjust according to your qualifications, skills and expertise.

Please send your cover letter referring to the position “Scientist – Translational Sciences” and resume specifying your scientific expertise and technical skills in bullet point format in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

Research Associate – Translational Sciences

Fixed-Term, 18 months

About X4 Pharmaceuticals:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on the Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a fixed-term for 18 months, full-time employment contract for a Research Associate –Translational Sciences.

 

Summary of the position:

We are looking for an experienced and highly motivated Research Associate – Translational Sciences with a strong background in immunology (B, T, monocytic, macrophage and NK cells) to support the development of in vitro assays and sample analyses of our translational in vivo research in primary immune deficiencies, cancers and neurodegeneration as well as new indications. Reporting to a scientist, the main duties will include:

  • Immune and/or neuronal cell research and establishment of new molecular biology techniques and protocols
  • Mammalian cell culture
  • Multi-colour flow cytometry, ELISA, WB, ELISpot and microscopy
  • Cell-based functional assays (migration, differentiation)
  • Routine molecular biology techniques (PCR, cloning)
  • Sample management and handling in a biosafety level 2 (BSL2) laboratory setting
  • General lab support

Qualifications and skills:

  • PhD in relevant field (e.g. cellular immunology, oncology, neurodegeneration, hematology), or Master degree with a minimum of 4 years of relevant research experience
  • Extensive experience with mammalian cell culture, cell-based assays, multi-colour flow cytometry including intracellular (cytokine) staining, serology, ELISA, WB and ELISpot
  • Experience working with bacterial/viral pathogens and patient samples in functional assays and BSL2 is an advantage
  • Ability to draft routine reports and keep accurate records of work performed
  • High accuracy, reliability, precision with sense of urgency
  • Organizational skills and flexible mind-set

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegiate working environment
  • Opportunities for your personal and career development and to play a key role in a growing international research center

 

In accordance with Austrian employment law, the minimum gross salary p.a. for the position is EUR 38.920,00 which we will adjust according to your qualifications, skills and expertise.

Please send your cover letter referring to the position “Research Associate – Translational Sciences” and resume specifying your technical skills in bullet point format in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

Research Associate – Discovery Department

About X4 Pharmaceuticals:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on the Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Research Associate – Discovery Department.

 

Summary of the position:

The Research Associate – Discovery Department will participate in developing ex vivo and in vitro models in immunology, oncology and/or neurology e.g. neurodegeneration. Reporting to a scientist, the main duties will include:

  • Establish immune cell-based assays to characterize candidate therapeutic molecules and their mode of action, particularly for B cell lymphomas and other blood cancers
  • Develop high-throughput assays for candidate drug identification
  • Research the role of CXCR4 in diseases associated with immune and neural cell disorders
  • Mammalian cell culture, Flow cytometry, ELISA, WB, microscopy
  • Cell-based assays (migration, differentiation, signalling, metabolism, proliferation, apoptosis)
  • Present data at internal and external meetings
  • General lab support

Qualifications and skills:

  • PhD degree in Immunology, Neurobiology or Cell Biology with strong wet-lab experience
  • Good understanding of immune disease pathways, immune cell biology, or infection biology
  • Extensive experienced with hematopoietic cell culture and differentiation
  • Experience with mammalian cell culture, transfections, cell-based ELISA, Flow cytometry and WB
  • Ability to draft routine reports and keep accurate records of work performed
  • High accuracy, reliability, precision under time pressure
  • Organizational skills and flexible mind-set
  • Experience with human iPSC or ESC culturing and differentiation (preferred but not required)
  • Experience with genetic engineering, CRISPR/Cas (preferred but not required)

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegiate working environment
  • Opportunities for your personal and career development and to play a key role in a growing international research center

 

In accordance with Austrian employment law, the minimum gross salary p.a. for the position is EUR 38.920,00 which we will adjust according to your qualifications, skills and expertise.

Please send your cover letter referring to the position “Research Associate – Discovery Department” and resume specifying your technical skills in bullet point format in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

Research Assistant – Discovery Department

About X4 Pharmaceuticals:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on the Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Research Assistant – Discovery Department.

 

Summary of the position:

The Research Assistant – Discovery Department will participate in developing in vitro models in immunology, oncology and neurology, with a main focus on primary immune deficiencies and genotype-phenotype correlation. Reporting to a scientist, main duties will include:

  • Mammalian cell culture
  • Routine molecular biology techniques (PCR, cloning)
  • Generation of stable cell lines
  • Flow cytometry, ELISA, WB, microscopy
  • Develop and perform cell-based assays to support therapeutic areas of interest (migration, differentiation)
  • General lab support

Qualifications and skills:

  • Bachelor, Master or equivalent with strong wet-lab experience
  • Extensive experience with mammalian cell culture, transfections, cell-based ELISA, Flow cytometry and WB preferably in the field of oncology, neurology and/or immunology
  • Experience with human iPSC or ESC culturing and differentiation (preferred but not required)
  • Experienced in hematopoietic cell culture (preferred but not required)
  • Experience with genetic engineering, CRISPR/Cas (preferred but not required)
  • Ability to draft routine reports and keep accurate records of work performed
  • High accuracy, reliability, precision under time pressure
  • Organizational skills and flexible mind-set

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegiate working environment
  • Opportunities for your personal and s and to play a key role in a growing international research center

 

In accordance with Austrian employment law, the minimum gross salary p.a. for the position is EUR 34.140,40 which we will adjust according to your qualifications, skills and expertise.

Please send your cover letter referring to the position “Research Assistant – Discovery Department” and resume specifying your technical skills in bullet point format in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

We invite you to apply for any of our current openings at careers-vienna@x4pharma.com for additional employment related information.

 

X4 Pharmaceuticals does not review or control the content on the website to which this hyperlink connects and this hyperlink does not constitute an endorsement by X4 Pharmaceuticals of the content of any non-X4 Pharmaceuticals website.

Continue