Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision
  • Say what they mean, and let their words match their actions
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

 

Open Positions

Location: Boston, MA USA

Click here to view and apply for position openings at X4’s Boston location.

Location: Vienna, Austria

Privacy Notice for applications of X4 Pharmaceuticals (Austria) GmbH in accordance with Article 13 of the General Data Protection Regulation (“GDPR”)
Scientist – Translational Sciences

About X4 Pharmaceuticals: 

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on the Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Scientist – Translational Sciences.

Summary of the Position:

We are looking for an experienced and highly motivated Scientist – Translational Sciences with a strong background in translational research and discovery including pharmacological and disease animal models as well as assays with clinical/human specimens for the mechanistic characterization of new therapies. The successful candidate will contribute to the identification, validation and characterization of novel targets and therapeutics, with a focus on primary immunodeficiencies and cancers as well as new indications including neurodegeneration. Reporting to the Senior Director, Translational Sciences, the main duties will include:

  • Work with an established team of Research Associates within the Translational Sciences Department
  • Collaborate with internal and external research teams and CROs to advance our translational research capabilities
  • Contribute to the identification and validation as well as project development processes for new therapeutic targets and indications
  • Select and perform pharmacological and efficacy studies in relevant animal models within a variety of therapeutic areas
  • Develop and execute on in vitro assays including biomarker studies to support clinical trials and mode-of-action studies of our compounds
  • Analyze and present data at internal and external meetings
  • Write reports and scientific publications

Qualifications and Skills:

  • PhD degree in relevant field (e.g. B and T cell immunology, oncology, hematology, neurobiology or cell biology)
  • Minimum of four years of post-doctoral and wet lab experience or corresponding industrial experience
  • Expertise in pharmacology and disease animal models
  • Strength in research and interpretation of large datasets and cross-functional studies in various disease indications
  • Extensive experience and trouble-shooting skills in relevant molecular biology techniques
  • Experience working within a Biosafety Level 2 laboratory including work with bacterial/viral pathogens and patient material as well as analysis and interpretation of sophisticated sequencing methods (e.g. scRNAseq), transcriptomics and/or proteomics in an advantage
  • Effective communication and relationship building skills with internal and external stakeholders
  • Independent, proactive, and hands-on team player with strategic thinking and sense of urgency
  • Ability to supervise and train laboratory staff

We are Offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegial working environment
  • Opportunities for your personal and career development and to play a key role in a growing international research center
  • Opportunity to work at the interface of pre-clinical research and clinical translational science

In accordance with Austrian employment law, the minimum gross salary p.a. for the position is EUR 48.690,60 which we will adjust according to your qualifications, skills and expertise.

Please send your cover letter referring to the position “Scientist – Translational Sciences” and resume specifying your scientific expertise and technical skills in bullet point format in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

Research Associate – Translational Sciences

Fixed-Term, 18 months

About X4 Pharmaceuticals:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on the Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a fixed-term for 18 months, full-time employment contract for a Research Associate –Translational Sciences.

Summary of the Position:

We are looking for an experienced and highly motivated Research Associate – Translational Sciences with a strong background in immunology (B, T, monocytic, macrophage and NK cells) to support the development of in vitro assays and sample analyses of our translational in vivo research in primary immune deficiencies, cancers and neurodegeneration as well as new indications. Reporting to a scientist, the main duties will include:

  • Immune and/or neuronal cell research and establishment of new molecular biology techniques and protocols
  • Mammalian cell culture
  • Multi-colour flow cytometry, ELISA, WB, ELISpot and microscopy
  • Cell-based functional assays (migration, differentiation)
  • Routine molecular biology techniques (PCR, cloning)
  • Sample management and handling in a biosafety level 2 (BSL2) laboratory setting
  • General lab support

Qualifications and Skills:

  • PhD in relevant field (e.g. cellular immunology, oncology, neurodegeneration, hematology), or Master degree with a minimum of 4 years of relevant research experience
  • Extensive experience with mammalian cell culture, cell-based assays, multi-colour flow cytometry including intracellular (cytokine) staining, serology, ELISA, WB and ELISpot
  • Experience working with bacterial/viral pathogens and patient samples in functional assays and BSL2 is an advantage
  • Ability to draft routine reports and keep accurate records of work performed
  • High accuracy, reliability, precision with sense of urgency
  • Organizational skills and flexible mind-set

We are Offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegiate working environment
  • Opportunities for your personal and career development and to play a key role in a growing international research center

In accordance with Austrian employment law, the minimum gross salary p.a. for the position is EUR 38.920,00 which we will adjust according to your qualifications, skills and expertise.

Please send your cover letter referring to the position “Research Associate – Translational Sciences” and resume specifying your technical skills in bullet point format in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

Research Assistant - Discovery Department

About X4 Pharmaceuticals:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on the Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Research Assistant – Discovery Department.

Summary of the Position:

The Research Assistant – Discovery Department will participate in developing in vitro models in immunology, oncology and neurology, with a main focus on primary immune deficiencies and genotype-phenotype correlation. Reporting to a scientist, main duties will include:

  • Mammalian cell culture
  • Routine molecular biology techniques (PCR, cloning)
  • Generation of stable cell lines
  • Flow cytometry, ELISA, WB, microscopy
  • Develop and perform cell-based assays to support therapeutic areas of interest (migration, differentiation)
  • General lab support

Qualifications and Skills:

  • Bachelor, Master or equivalent with strong wet-lab experience
  • Extensive experience with mammalian cell culture, transfections, cell-based ELISA, Flow cytometry and WB preferably in the field of oncology, neurology and/or immunology
  • Experience with human iPSC or ESC culturing and differentiation (preferred but not required)
  • Experienced in hematopoietic cell culture (preferred but not required)
  • Experience with genetic engineering, CRISPR/Cas (preferred but not required)
  • Ability to draft routine reports and keep accurate records of work performed
  • High accuracy, reliability, precision under time pressure
  • Organizational skills and flexible mind-set

We are Offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegiate working environment
  • Opportunities for your personal and s and to play a key role in a growing international research center

In accordance with Austrian employment law, the minimum gross salary p.a. for the position is EUR 34.140,40 which we will adjust according to your qualifications, skills and expertise.

Please send your cover letter referring to the position “Research Assistant – Discovery Department” and resume specifying your technical skills in bullet point format in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

We invite you to apply for any of our current openings at careers-vienna@x4pharma.com for additional employment related information.

 

X4 Pharmaceuticals does not review or control the content on the website to which this hyperlink connects and this hyperlink does not constitute an endorsement by X4 Pharmaceuticals of the content of any non-X4 Pharmaceuticals website.

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