Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision
  • Say what they mean, and let their words match their actions
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

Open Positions

Location: Cambridge MA, USA

Director, New Product Planning

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in Phase 3 development for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof of concept in WHIM in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. A Phase 2 open label extension study for WHIM is ongoing. Mavorixafor was designated orphan drug status by the U.S. Food and Drug Administration in 2018 for the treatment of WHIM and is also in development for Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4 is also developing X4P-002, a CXCR4 antagonist that has unique properties that the company believes will enable penetration of the blood-brain barrier and provide appropriate therapeutic exposures to treat brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Chief Financial Officer, the Director, New Product Planning will be responsible for designing and executing product and disease level strategies to advance Mavorixafor in WHIM Syndrome, cancers and other primary immune deficiency diseases. The candidate will join the X4 team in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in New Product Planning, Global Market Access, and early drug development who thrives in a team-oriented, fast-paced, and cross-disciplinary biotech environment. Prior experience in industry as commercial and/or market access lead required. Rare disease experience preferred.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

 

Scope of Work and Responsibilities:

  • Conduct rigorous market assessment(s) to define commercial development strategy for Mavorixafor. Define overall commercial product strategic plan through phase 3 and beyond including life cycle management
  • Analyze target markets to determine current and future treatment paradigms, competitive landscape, unmet need, product positioning and value proposition
  • Act as commercial champion on program teams and lead commercial sub-teams to ensure that customer needs are incorporated into all development and life cycle management plans
  • Define and maintain a target product profile (TPP) and minimum product profile (MPP) to guide research discovery development go/ no go decisions
  • Build preliminary forecasting models to quantify market and product opportunities, including sensitivity analyses to validate key value driven assumptions. Maintain the revenue forecasts based on TPPs/MPPs for each program in development
  • Develop market access plans based on unique characteristics of target markets, and work with program teams to ensure appropriate clinical trial design to deliver data/endpoints required for reimbursement (market research, ad boards, etc.)
  • Drive early brand message development, including collaboration with public relations and medical affairs/medical communications (publication plans, continuing medical education/congress activities)
  • In collaboration with internal advocacy partners, define and develop both professional and patient advocacy plans and establishing strong relationships with key stakeholders, including overseeing sponsorships
  • Develop and execute early life-cycle management initiatives, including follow-on indication analyses and global expansion opportunities
  • Oversee generic and brand naming initiatives for pipeline programs
  • A key partner in the evaluation of potential alliances for product candidates
  • Collaborate with Medical Affairs and Clinical to define therapeutic areas, therapeutic targets and technologies of interest.
  • Develop 1- and 5-year strategic commercialization plans for each product candidate
  • Collaborate with finance to put together an annual commercial budget based on highest priority spend/activities for each candidate, enabling achievement of short- and long-term plans; manage budget for each program candidate
  • Ensure that coverage, reimbursement, pricing value evidence, and policy are integrated into the strategic plan that supports the overarching commercial position and links back to the clinical attributes of the candidate serving to advance X4’s knowledge and readiness for the global access environment
  • Work with leadership to create commercial launch build-out plan, resources and timelines that align with overall strategic plans for individual products
  • Build orphan drug market access and indication backgrounders for senior leadership and others in the organization as needed (other topics may also be required)

 

Qualifications and Professional Experience:

  • Bachelor’s Degree required with a minimum of 5-7 years in Ultra Rare/Rare Disease new products marketing/planning/launch and/or marketing research for early stage products role with a strong preference for biotechnology experience.
  • Orphan drug experience
  • Analytical expertise
  • Solid understanding of pharmaceutical development path from discovery to launch and ability to identify strategic and operational choices that could impact successful commercialization
  • Strong organizational and project management skills, ability to drive projects to completion in scientifically driven company
  • Established ability to work collaboratively across functions and maintain strong working relationships with key stakeholders
  • Strong written, verbal and presentation skills with all levels of an organization

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Director/Associate Director of Biostatistics

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in Phase 3 development for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof of concept in WHIM in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. A Phase 2 open label extension study for WHIM is ongoing. Mavorixafor was designated orphan drug status by the U.S. Food and Drug Administration in 2018 for the treatment of WHIM and is also in development for Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4 is also developing X4P-002, a CXCR4 antagonist that has unique properties that the company believes will enable penetration of the blood-brain barrier and provide appropriate therapeutic exposures to treat brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Senior Director, Biostatistics the Director/Associate Director of Biostatistics will be responsible for providing leadership and oversee all biostatistics activities for one disease area or clinical program(s) to ensure valid and efficient statistical designs, accurate analyses, and timely delivery of reports and regulatory submissions. She/he builds and maintains strong collaboration with key stakeholders from different disciplines across the organization (e.g., Clinical Physicians, Clinical Operations, Regulatory, Medical Affair, and Safety teams) to develop agile and robust clinical development plans. She/he contributes to establishing and driving the strategy for resourcing, processes and standards operating procedures. This individual is responsible for the production of biostatistics deliverables as well as accountable for the strength of the partnership and the results of our external resources. She/he will be managing a team of external vendors: CRO’s, statisticians, stats programmers, data managers and will support the development of the internal biostatistics team accordingly. A successful candidate is an excellent communicator, self-motivated, and forward thinking.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

 

Scope of Work and Accountabilities:

  • Oversee statistical support for phase II and phase III studies for rare disease program.
  • Collaborate with clinical and regulatory leads in defining strategic approach, creating clinical development plans (CDP), and producing individual protocols.
  • Provides strategic contributions to the clinical study programs, including study designs, protocol development, statistical analysis plans, data analysis and reporting, as well as key contributions to the planning and delivery of clinical components of regulatory submissions including INDs, NDAs and MAAs.
  • Manage the execution of statistical analyses; preparation of the statistical methods and results sections for clinical study reports (CSR), and production of overall summaries.
  • Serve as the statistical representative at cross-functional team meetings.
  • Responsible for completing CDISC requirements for SDTM and ADaM.
  • Develop and track project activities for phase II and III studies to ensure all timelines are met.
  • Provide lead oversight to vendor team to ensure quality and consistency of statistical deliverables.
  • Learn and apply techniques to promote teamwork, quality, and motivation. Ability to manage conflict, prioritize daily tasks and adapt to changes.
  • Keep abreast of innovative statistical methodologies in study design and analysis, industry standards, regulatory requirements, and internal SOPs.
  • Advocate application of statistical thinking in decision-making. Effective collaboration with leaders in other functional areas.

 

Qualifications and Professional Experience:

  • D/MS in Statistics or Biostatistics with a minimum of 7/10 years of pharmaceutical experience.
  • Substantial interactions with global regulatory authorities which include the FDA, EMA, and PMDA.
  • BLA/NDA/MAA submission experiences.
  • Demonstrated leadership, project management, adapting to changes, and effective partnership
  • Ability to explain methodology and consequences of decisions to a variety of audiences who do not have stats expertise.
  • Demonstrated experience developing effective and sustained partnerships with external partners, including CRO’s and Consultants.
  • Broad knowledge and application of advanced statistical concepts and techniques.
  • Extensive knowledge of major statistical software programs including SAS.
  • Exceptional oral, written, presentation, and communications skills.
  • Embrace our core values: Accountability, Excellence, Grit, Integrity, Sense of Urgency, and Camaraderie.

 

The above statements are intended to describe the general nature and level of work being performed.  They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce.  All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.   Please send your resume and cover letter to careers@x4pharma.com.  

Medical Science Liasion – West Region

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in Phase 3 development for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof of concept in WHIM in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. A Phase 2 open label extension study for WHIM is ongoing. Mavorixafor was designated orphan drug status by the U.S. Food and Drug Administration in 2018 for the treatment of WHIM and is also in development for Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4 is also developing X4P-002, a CXCR4 antagonist that has unique properties that the company believes will enable penetration of the blood-brain barrier and provide appropriate therapeutic exposures to treat brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Vice President, Medical Affairs the Medical Science Liaison is/will be responsible for for providing non-promotional scientific, educational, and research support for X4 Pharma Rare Disease clinical program. The MSL position is a field-based member of the Medical Affairs team. The MSL should be highly trained in a health care field and well-versed in clinical practice. A primary focus of this role and basis for measuring MSL performance is to identify WHIM syndrome patients and their treating physicians, support acceleration of WHIM clinical program through identification of new clinical sites, collaboration with existing sites, and/or enrollment of appropriate patients in company-sponsored clinical trial.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

 

Scope of Work and Responsibilities:

  • Design strategy to produce awareness of WHIM syndrome in the community and academic centers
    • Build relationships with investigators and internal stakeholders to identify physicians treating WHIM syndrome to encourage patient enrollment in company-sponsored clinical trial
    • Identify new physicians currently managing patients with WHIM syndrome (either diagnosed or undiagnosed) and cultivate a network of experts for treatment of WHIM in academic and community centers
    • Conduct and implement a comprehensive disease awareness tactical plan within the respective geography. Facilitate the identification of medical community educational needs around disease state and its diagnostic pathway
    • Identify and communicate key clinical and research insights from industry leaders appropriately with internal stakeholders to help shape company research, development, and strategies for investigational product
  • Formulate and Deliver diagnostic algorithm for WHIM syndrome
    • Collaborate with health care professionals to identify opportunities for the development of algorithms and guidelines to facilitate early diagnosis
    • Collaborate with medical affairs and clinical team to coordinate and optimize educational and research support for sites/investigators participating in X4’s clinical trial
  • Identify and support physicians with patients with WHIM syndrome
    • Support community and academic physicians with potential WHIM patients to enroll in the X4 sponsored genetic testing program “PATH4WARD”
    • Respond to unsolicited requests regarding interest in investigator sponsored studies (ISS), and support their submissions through appropriate internal processes
    • Serve as the liaison between intended parties such as: health care professionals, professional organizations, and disease state advocacy groups for research grant request and insights
  • Covering a large geography for the West Coast which will require 75-80% travel (including overnight stays)

 

Operational Requirements:

  • Comply with regulatory and compliance guidelines and company policies in all aspects of scientific dissemination of information to include responses to unsolicited requests for medical information
  • Address administrative and reporting needs on a timely basis or as requested by management, including documenting of MSL activities into CRM as required
  • Maintain understanding and competence in the following areas:
    • X4 Pharmaceuticals including Medical Affairs Field mission
    • Company vision and operating principles
    • Scientific data and objectives
    • Regulatory and health care compliance guidelines
    • Corporate policies on appropriate business conduct and ethical behavior
  • Continually monitor the medical environment to sustain expertise in WHIM disease state management and new therapies, competitive products and features; assess implications for company

 

Qualifications and Professional Skills:

  • Advanced degree in clinical specialty (PharmD, PhD, MD) and 5+ years of industry experience in rare disease. Must be experienced in community and academic setting
  • Proven success in developing relationships with referral physicians including immunology, dermatology, and ENT
  • Utilize ones already existing relationships in pediatric/adult non-oncology hematology
  • Experience in clinical research, patient recruitment, and investigator sponsored trials
  • Skills and competencies required:
    • Strong oral and written communication skills, skilled at presenting scientific content
    • Self-starter, highly accountable, and skilled problem solver
  • Passionate about making a meaningful difference for patients

 

The above statements are intended to describe the general nature and level of work being performed.  They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce.  All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.   Please send your resume and cover letter to careers@x4pharma.com.  

Senior Director, Regulatory Affairs

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in Phase 3 development for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof of concept in WHIM in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. A Phase 2 open label extension study for WHIM is ongoing. Mavorixafor was designated orphan drug status by the U.S. Food and Drug Administration in 2018 for the treatment of WHIM and is also in development for Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4 is also developing X4P-002, a CXCR4 antagonist that has unique properties that the company believes will enable penetration of the blood-brain barrier and provide appropriate therapeutic exposures to treat brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Vice President, Regulatory Affairs and Program Management, the Senior Director, Regulatory Affairs will be responsible for leading and implementing the global regulatory strategic plans for the development of current and future indications in conjunction with the regulatory therapeutic leads. The individual must possess excellent leadership judgment, organizational and planning experience along with exceptional written, verbal and electronic communication skills. The successful candidate will also have the ability to influence and negotiate professionally at all levels of the organization within project teams, and with strategic external partners, while maintaining positive working relationships.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

 

Scope of Work and Accountabilities:

The Senior Director, Regulatory Affairs is responsible for developing, implementing, and advising on global regulatory strategies for development programs to secure and maintain market access for product(s) in line with business objectives, and in coordination with key internal stakeholders.

He/She will manage regulatory aspects of compounds through all phases of development, postapproval, and life-cycle of the product. The incumbent will provide leadership and strategic regulatory oversight on projects including, but not limited to general regulatory strategies, regulatory requirements for clinical studies and marketing approval in domestic and international markets, regulatory strategic development plans and risk assessments, critical issue management and advice on Health Authority.

The individual will have departmental and corporate level influence and accountabilities and serves as an advisor/liaison to senior management to plan, evaluate and recommend regulatory strategy. Externally, the individual will interface with outside regulatory agencies and business partners regarding development, regulatory, and registration strategies. He/she may have line management, people development and performance management responsibilities, as well as support/lead development and implementation of department policies. The candidate will also act as the regulatory head as the surrogate for the Vice President, Regulatory Affairs and Program Management.

  • Provides high level strategic and operational regulatory direction and risk assessment for designated projects ensuring that the latest requirements and standards are met
  • Drives and is accountable for the preparation and submission of documentation to support investigational and marketing registration packages throughout the US & Global markets
  • Reviews and provides expertise for the sections of IND/CTA, NDA/MAA, and other global submission documents in support of clinical trials and marketing applications, and their amendments in conformance with local regulatory requirements
  • Liaises and negotiates with global regulatory authorities as needed for all aspects of drug development, including resolution of key regulatory issues and expediting approvals of product and labeling activities
  • Maintains awareness of the current global regulatory environment and assesses the impact of changes on business and product development programs and corporate risk
  • Facilitates the policy and development of the standard interpretation of global regulations
  • Integrates functional expertise with business knowledge to assess risk, solve problems and recommend solutions
  • Develop and implement creative approaches to ensure complaint regulatory success with the ability to innovate, analyze, and solve problems
  • Teach, develop and manage a high performing team, via direct and indirect reporting structures
  • Develops strong partnerships with cross functional senior key stakeholders to ensure that strategic business goals are met through the sharing of knowledge and teamwork
  • Brings expertise to the development and implementation of regulatory processes
  • Recruits, develops, leads and mentors top performing regulatory professionals, and helps create a goal-oriented culture

 

Qualifications and Professional Experience:

  • Bachelor’s degree required, advanced degree preferred
  • A minimum of 10 years in the biotechnology and/or biopharmaceutical industry
  • Minimum seven years in a Regulatory capacity with experience in several therapeutic areas, preferably in biotech and biopharma through commercialization
  • Preferred candidates will have experience working as a lead in Regulatory Affairs across two or more major geographic areas and prior experience with both small molecules and biologics
  • Proven experience as a respected leader of high performing talent
  • Expert in global regulatory guidelines required to lead the overall regulatory strategy
  • Demonstrated experience interacting with the Food and Drug Administration (FDA), European Medicines Agency (EMA), and other regulatory agencies
  • Proven leadership experience in the establishment and submission of INDs and approvals of NDAs and BLAs
  • Expertise in the drug development process with experience in multiple phases (early and late stage, post-approval) in various therapeutic areas
  • Understanding and implementing the life-cycle of a product from Phase III to commercialization within a Regulatory capacity

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

We invite you to apply for any of our current openings at careers@x4pharma.com for additional employment related information.

Location: Vienna, Austria

Scientist, Molecular and Cell Biology

About X4 Pharmaceuticals

Our commitment is to find solutions for patients. Every day, we strive to advance our pipeline of innovative medicines to treat rare diseases. Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer.

X4 Pharmaceuticals, Inc. was founded and is led by a team with deep product development and commercialization expertise, including several former members of the Genzyme leadership team and has its headquarter located in Cambridge, Massachusetts.

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Scientist – Molecular and Cell Biology.

 

Summary of the position:

The Scientist – Molecular and Cell Biology will establish and develop in vitro models of PIs and rare cancers, with focus on genotype-phenotype correlation. Main duties will be to:

  • Analyze genomic data to identify variants of specific target genes or pathways
  • Design, implement and develop in vitro assays to functionally and structurally characterize the gene variants identified, including protein-protein interaction studies, chemotaxis, Ca2+ flux, in various cell types
  • Develop high-throughput assays based on pilot studies
  • Structure, analyse and critically evaluate large sets of data
  • Present data at internal and external meetings
  • Write reports and scientific publications

 

Qualifications and skills:

  • PhD in Cell and Molecular Biology with at least two years of post-doctoral experience or corresponding biotech experience
  • Solid hands/on experience with molecular cloning, mammalian cell culture, transient and stable transfections
  • Extensive experience with flow cytometry, cell-based ELISA, chemotaxis, Ca2+ flux
  • In depth knowledge and experience working with GPCRs
  • Ability to supervise and train laboratory staff
  • Bioinformatics, gene set analysis (preferred but not required)
  • Genome editing (preferred but not required)
  • Previous work with CXCR4 and pathway genes (preferred but not required)
  • Experience with protein-protein interaction studies (preferred but not required)
  • Previous experience with BRET assays (preferred but not required)

 

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegial working environment
  • Opportunities for your personal development and to play a key role in a growing international research center
  • Opportunity to work at the interface of pre-clinical research and clinical translational science

 

In accordance with Austrian employment law, the minimum monthly gross salary for the position is EUR 3.348,82 which we are willing to adjust according to your qualifications, skills and expertise.

Please send your resume and cover letter in English to careers-vienna@x4pharma.com

Scientist, Immunology and In Vitro Models

About X4 Pharmaceuticals

Our commitment is to find solutions for patients. Every day, we strive to advance our pipeline of innovative medicines to treat rare diseases. Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer.

X4 Pharmaceuticals, Inc. was founded and is led by a team with deep product development and commercialization expertise, including several former members of the Genzyme leadership team and has its headquarter located in Cambridge, Massachusetts.

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Scientist – Immunology and In Vitro Models.

 

Summary of the position:

As part of our team, the Scientist – Immunology and In Vitro Models will

  • Perform research in the field of rare primary immunodeficiencies and cancer
  • Be responsible for the planning, coordination, documentation, and execution of laboratory experiments in the areas of immunology and cell biology
  • Establish novel cell based in-vitro and ex-vivo immune models, using (primary) human immune cells, for evaluation and mode of action studies of new therapeutics
  • Present data at internal and external meetings and extend knowledge by attending scientific conferences
  • Support the team in writing reports and manuscripts

 

Qualifications and skills:

  • PhD or Post Doc in immunology, molecular biology or a related discipline
  • Experience in the development of bioassays
  • Strong experience in mammalian cell culture including isolation and propagation of human and mouse immune cells
  • Hands-on experience in human and murine cellular immunology methods using primary and expanded immune cells (e.g. T cells, B cells, myeloid cells, co-culture assays and other primary cell assays)
  • Experience in analysis of proteins and cytokines by single and multiplex platforms
  • Experience in multi-color flow cytometry and fluorescence microscopy
  • Experience with DNA cloning and gene manipulation methods
  • Prior research experience in immunodeficiencies and or GPCRs is a plus
  • Clear ambition to learn about and implement new technologies and open to new challenges
  • Proficiency in data analysis and presentation tools
  • Proven ability to troubleshoot technical and scientific issues
  • Excellent oral and written communication skills in English
  • Collaborative team player attitude

 

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegial working environment
  • Opportunities for your personal development and to play a key role in a growing international research center

 

In accordance with Austrian employment law, the minimum monthly gross salary for the position is EUR 3.348,82 which we are willing to adjust according to your qualifications, skills and expertise.

Please send your resume and cover letter in English to careers-vienna@x4pharma.com

Technician, Molecular and Cell Biology

About X4 Pharmaceuticals

Our commitment is to find solutions for patients. Every day, we strive to advance our pipeline of innovative medicines to treat rare diseases. Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer.

X4 Pharmaceuticals, Inc. was founded and is led by a team with deep product development and commercialization expertise, including several former members of the Genzyme leadership team and has its headquarter located in Cambridge, Massachusetts.

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Technician – Molecular and Cell Biology.

 

Summary of the position:

The Technician – Molecular and Cell Biology will participate in developing in vitro models of primary immune deficiencies and rare cancers, with a focus on genotype-phenotype correlation. Main duties will mainly include:

  • Mammalian cell culture
  • Routine molecular biology techniques (PCR, cloning)
  • Flow cytometry, ELISA, WB
  • Cell based assays (chemotaxis, Ca2+ flux)
  • General lab support

 

Qualifications and skills:

  • Bachelor, Master, or PhD degree (or equivalent) with strong wet-lab experience
  • Extensive experience with mammalian cell culture, transfections, cell based ELISA, Flow cytometry and WB
  • Ability to draft routine reports and keep accurate records of work performed
  • High accuracy, reliability, precision under time pressure
  • Organizational skills and flexible mind-set
  • Previous work with GPCRs (preferred but not required)
  • Experience with protein-protein interaction studies (preferred but not required)

 

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegial working environment
  • Opportunities for your personal development and to play a key role in a growing international research center

 

In accordance with Austrian employment law, the minimum monthly gross salary for the position is EUR 2.676,83 which we are willing to adjust according to your qualifications, skills and expertise.

Please send your resume and cover letter in English to careers-vienna@x4pharma.com

We invite you to apply for any of our current openings at careers-vienna@x4pharma.com for additional employment related information.

 

X4 Pharmaceuticals does not review or control the content on the website to which this hyperlink connects and this hyperlink does not constitute an endorsement by X4 Pharmaceuticals of the content of any non-X4 Pharmaceuticals website.

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