Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision
  • Say what they mean, and let their words match their actions
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

Open Positions

Location: Boston MA, USA

Director, Medical Communications and Publications

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Vice President, Medical Affairs, Director of Medical Communications and Publications is/will be responsible for providing non-promotional scientific, educational, and research support for X4’s Rare Disease and oncology portfolio. This HQ-based role serves as a clinical expert who strategically supports the medical and scientific objectives of X4’s development and marketed programs. S/he will be responsible for communicating the science and clinical application of X4’s molecules across all therapeutic areas to the medical community and payers. This individual will lead the development and execution of scientific data dissemination strategy for all therapeutic areas within X4. S/he will also be responsible for gathering scientific insights from KOLs to inform strategic planning and improve the positioning of X4 in the therapeutic areas of interest. Overtime, this role will lead and manage a team of medical communication and publication professionals to help bring transformative therapies to patients with unmet medical needs.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

 

Scope of Work and Accountabilities:

  • Lead and drive the development of publications, including abstract submissions to medical congresses, posters, and platform presentations.
  • Responsible for the development of medical education initiatives, including live education programs, congress symposia, online education, multichannel HCP education, field medical tools, slide decks, and medical booth resources.
  • Initiate and develop core communication strategic tools such as the scientific platform, narrative, lexicon, FAQs/backgrounders, standard response letters, and advisory board content.
  • Establish and maintain collaborative business partnerships with clinical, medical affairs and program leads to align on medical communications strategy across all X4 programs.
  • Develop and execute a global publication and medical communication plans for the organization related to all programs.
  • Ensure appropriate tracking and execution of the publications tactical and medical communication plan in accordance with established priorities and company key performance indicators.
  • Ensure key data is strategically aligned with scientific communication points, elements from other internal guidance and resource documents are included appropriately in all publications, and that the conclusions are supported by data.
  • Provide medical input to brand teams regarding strategy, tactics, and development of claims.
  • Serve as an internal disease state and product expert for training of medical and commercial colleagues.
  • Engage with KOLs as authors for publications and advisors for medical communication initiatives.
  • Participate in budget forecasting and long-range planning for strategic growth within the department.
  • Attend key international and national medical conferences to support medical affairs activities.
  • Provide input into the planning and execution of advisory boards and MSL roundtables.
  • Lead gap analysis to identify and address medical education and data/evidence gaps.
  • Provide input into clinical and Phase IV/investigator-sponsored studies, including disease and product registries to support integrated evidence generation plan.
  • Accountable for meeting corporate goals and objectives in compliance with applicable policies and regulations.

 

Qualifications and Professional Experience:

  • Advance degree in life sciences or pharmaceutical sciences (PhD, PharmD, or MD) with 8+ years of relevant medical affairs experience.
  • A minimum of 8-10 years pharma/biotech industry global or US experience highly preferred.
  • Rare Disease and/or Oncology experience preferred, but not required.
  • Ability to interpret and critique scientific and medical literature with respect to scientific and business implications.
  • Experience and demonstrated skill in the analysis, communication and presentation of complex scientific and medical data.
  • Knowledge of industry guidelines pertaining to data dissemination (e.g., CONSORT, ICMJE, GPPs) and interactions with health care providers (e.g., PhRMA).
  • Track record of successfully developing peer-reviewed publications is required.
  • Ability to collaborate with external Key Opinion Leaders on data dissemination strategies in a credible, responsive and scientific manner.
  • Excellent interpersonal and communication skills, written and verbal; comfortable and experienced in making presentations.
  • Demonstrated ability to work effectively in a matrix environment.
  •  Creative problem-solver with strong business acumen and skills.
  • Exceptional time management and organizational skills.
  • Require 20-30% travel both domestic and international.
  • Passionate about making a meaningful difference in patient care.

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Associate Director/Director of Biostatistics

Company Description: 

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Comission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Vice President, Biostatistics the Director/Associate Director of Biostatistics will be responsible for providing leadership and oversee all biostatistics activities for oncology and rare disease areas for clinical program(s) to ensure valid and efficient statistical designs, accurate analyses, and timely delivery of reports and regulatory submissions. She/he will build and maintain a strong collaboration with key stakeholders from different disciplines across the organization (e.g., Clinical Physicians, Clinical Operations, Regulatory, Medical Affair, and Safety teams) to develop agile and robust clinical development plans. She/he contributes to establishing and driving the strategy for resourcing, processes, and standards operating procedures. This individual is responsible for the production of biostatistics deliverables as well as accountable for the strength of the partnership and the results of our external resources. She/he will be managing a team of external vendors: CRO’s, statisticians, stats programmers, data managers and will support the development of the internal biostatistics team accordingly. A successful candidate is an excellent communicator, self-motivated, and forward thinking.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions, and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

 

Scope of Work and Accountabilities:

  • Oversee statistical support for phase II and phase III studies for oncology and rare disease programs.
  • Collaborate with clinical and regulatory leads in defining strategic approach, creating clinical development plans (CDP), and producing individual protocols.
  • Provide strategic contributions to the clinical study programs, including study designs, protocol development, statistical analysis plans, data analysis and reporting, as well as key contributions to the planning and delivery of clinical components of regulatory submissions including INDs, NDAs and MAAs.
  • Manage and drive the execution of statistical analyses; preparation of the statistical methods and results sections for clinical study reports (CSR), and production of overall summaries.
  • Serve as the statistical representative at cross-functional team meetings.
  • Responsible for completing CDISC requirements for SDTM and ADaM.
  • Develop and track project activities for phase II and III studies to ensure all timelines are met.
  • Oversee vendor team to ensure quality and consistency of statistical deliverables.
  • Learn and apply techniques to promote teamwork, quality, and motivation. Ability to manage conflict, prioritize daily tasks and adapt to changes.
  • Keep abreast of innovative statistical methodologies in study design and analysis, industry standards, regulatory requirements, and internal SOPs.
  • Advocate application of statistical thinking in decision-making. Effective collaboration with leaders in other functional area

 

Qualifications and Professional Experience:

  • PH.D/MS in Statistics or Biostatistics with a minimum of 7/10 years of Pharmaceutical/Biotechnology industry
  • Deep experience of interactions with global regulatory authorities which include the FDA, EMA, and PMDA.
  • BLA/NDA/MAA submission experiences.
  • Demonstrated leadership, project management, adapting to changes, and effective partnership
  • Ability to explain methodology and consequences of decisions to a variety of audiences who do not have stats expertise.
  • Deep understanding and experience developing effective and sustained partnerships with external partners, including CRO’s and Consultants.
  • Broad knowledge and application of advanced statistical concepts and techniques.
  • Extensive knowledge of major statistical software programs including SAS.
  • Exceptional oral, written, presentation, and communications skills.


The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Medical Science Liaison / Senior Medical Science Liaison - West Coast

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Comission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Vice President, Medical Affairs, the Medical Science Liaison is/will be responsible for providing non-promotional scientific, educational, and research support for X4’s Rare Disease and oncology portfolio. The MSL is a field-based scientific and clinical expert who strategically supports the medical and scientific objectives of X4’s development and marketed programs. S/he will be responsible for communicating the science and clinical application of X4’s molecules across all therapeutic areas to Healthcare Practitioners (HCPs). This individual will ensure the delivery of cutting edge clinical and scientific data and technical/practical education to practicing clinicians, key thought leaders, professional societies, and payers. S/he will also be responsible for gathering appropriate and relevant scientific insights from KOLs in an expeditious manner that will aid in strategic planning, enhance the quality of clinical research, increase the accuracy of assessments, and improve the positioning of X4 in the therapeutic areas of interest.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.


Scope of Work and Accountabilities:

  • Within respective geography, identifies, develops, and maintains effective professional relationships with critical external stakeholders to build a network of Key Opinion Leaders for research initiatives, scientific advisory boards and other opportunities for medical and scientific collaboration.
  • Develop and implement a comprehensive disease awareness plan within the respective geography including roundtables, grand rounds and other educational initiatives.
  • Partner closely with investigators and internal stakeholders for clinical trial enrollment and site identification.
  • Provide in-depth drug and disease state information to health care providers in the respective geography.
  • Attend key medical congresses at the national level and regional society meeting supporting scientific and corporate goals.
  • Remain up to date on relevant science and competitive landscape.
  • Serve as a liaison to health care professionals and professional organizations and disease state advocacy groups. Support the efforts of patient support groups and educational foundations.
  • Provide medical and scientific input into the planning and execution of advisory boards and MSL roundtables. Work with KOLs to review presentations and provide additional medical education where requested.
  • Respond to unsolicited requests regarding interest in investigator sponsored studies (ISS) and support their submission through appropriate internal process.
  • Accountable for meeting corporate goals and objectives while keeping in compliance with applicable policies and regulations.
  • Require 60-70% travel.


Qualifications and Professional Experience:

  • PharmD, PhD, MD preferred, but will consider NP/PA/MSN with clinical experience.
  • Minimum 8 -10 years of MSL experience (or equivalent).
  • Rare Disease and/or Oncology experience preferred, but not required.
  • Creative problem-solver with strong business acumen and skills.
  • Exceptional time management and organizational skills.
  • Proven track record of success in establishing relationships with opinion leaders.
  • Ability to understand and clearly communicate evidence based scientific information.
  • Ability to work collaboratively and cross-functionally showing sound decision making and accountability.
  • Experience in clinical research, patient recruitment, and investigator sponsored trials.
  • Passionate about making a meaningful difference in patient care.
  • Ability to engage in cross-functional interactions with internal and external staff Strong verbal and written communications skills, as well as problem-solving skills.


The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Human Resources Coordinator

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Manager, Human Resources, the HR Coordinator is responsible for adding ideas, energy, and empathy to the HR Team. S/he will perform and enhance various support and transactional activities to support Human Resources Operations. This role is highly visible, representing the Company and HR team across all departments and with external partners supporting various confidential operational deliverables. Success will depend on establishing and maintaining effective and trusted working relationships across the organization, especially with the Finance team, to deliver timely and accurate results. This opportunity includes supporting the Senior Vice President of Human Resources, providing scheduling, presentations, and other support, as needed. This is an excellent opportunity for an ambitious, eager professional to gain knowledge and exposure to a publicly-traded company’s broader Human Resources function.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

 

Scope of Work and Accountabilities:

  • Supporting and improving day-to-day HR Operations activities always embracing professionalism, discretion and a commitment to the highest standards of service and integrity. Areas of responsibilities will include:
    •  Benefits Administration and Compliance
      • Updated and compliant coordination and retention of confidential HR records, including resumes, job descriptions, offer letters, background checks and other required documents resulting in successful periodic audits.
      • Leading the timely and accurate collection of signed corporate policy acknowledgments and other company-wide information.
      • Accurate and timely updating of Organization Charts, including confidential information
      • Ownership of the HR Calendar, Global Holiday Calendar, and corporate distribution lists
    • Benefit Administration
      • Understanding and explanation of benefit plans
      • Guiding new employees through the enrollment process via HRIS ensuring a positive experience
      • Enrollments and/or adjustments to elections on carrier websites
      • Support in the annual Open Enrollment process for company benefits
    • Serving as a collaborative and integrated partner with Finance on confidential payroll and benefits related matters.
  • Accurate and timely entry of confidential data and ongoing changes in the HRIS system, including employee onboarding, benefit elections, reporting and employment related changes.
  • Partner with the HR team to optimize department tools and processes to maximize efficiency in all capacities with precision and meeting compliance requirements.
  • Delivering regular and updated reports and data analysis, including HR metrics, compliance reporting, training attendance, and headcount reporting.
  • Support of Performance Management objectives, including goal setting audits, mid-year review tracking, and the year-end performance cycle.
  • Employing a continuous improvement sensibility, anticipate and provide suggestions on process gaps, systems limitations/improvements, and workflows efficiency and integration.
  • Calendar management, PowerPoint and excel support for the Senior Vice President, Human Resources

 

Qualifications and Professional Experience:

  • Bachelor’s degree in Human Resources or a business-related focus preferred.
  • Minimum of 2 years of HR experience required in a publicly-traded company. Biotech or bio-pharma is preferred
  • Proven professional integrity, diplomacy, high-touch service, resourcefulness. A “People and Patient first” mentality
  • Desire and energy to be part of a high- performing, innovative team in a high growth and fast-paced culture where how you do what you do is important.
  • Proven experience in work delivery with a passion for high accuracy, deep attention to detail and improving business processes and workflows.
  • Strong and thoughtful verbal, written and electronic communications skills.
  • Deep and vibrant intellectual curiosity to learn new things and take the initiative to research and explore solutions.
  • Strong awareness of the use of judgment, discretion, and a high degree of professionalism/confidentiality
  • Naturally highly organized and proven competency with multiple and shifting priorities on a regular basis.
  • Experience and comfort balancing, independent work, integrating with the HR team, and communicating cross-functionally with levels of the organization and external partners.
  • Known for dedication to problem solving and customer service with a high level of resourcefulness.
  • Advanced experience with MS Excel, WORD and PPWT. ADP Workforce Now, Smartsheet, SharePoint, and Concur experience a highly desirable.

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

We invite you to apply for any of our current openings at careers@x4pharma.com for additional employment related information.

Location: Vienna, Austria

Privacy Notice for applications of X4 Pharmaceuticals (Austria) GmbH in accordance with Article 13 of the General Data Protection Regulation (“GDPR”)

We invite you to apply for any of our current openings at careers-vienna@x4pharma.com for additional employment related information.

 

X4 Pharmaceuticals does not review or control the content on the website to which this hyperlink connects and this hyperlink does not constitute an endorsement by X4 Pharmaceuticals of the content of any non-X4 Pharmaceuticals website.

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