Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision
  • Say what they mean, and let their words match their actions
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

Open Positions

Location: Cambridge MA, USA

New Product Planning Director, Commercial

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4’s lead product candidate, mavorixafor (X4P-001), has completed a Phase 2 trial in patients with a rare genetic PI called Warts, Hypogammaglobulinemia, Infections, and Myelokathexis, or WHIM syndrome. X4 plans to initiate a Phase 3 pivotal trial of mavorixafor in patients with WHIM syndrome. In addition to the initial focus on WHIM syndrome, X4 believes that the biological rationale and available data on mavorixafor support potential therapeutic benefits across a broad range of PIs, including Severe Congenital Neutropenia as well as hematologic and solid organ cancers including Waldenström Macroglobulinemia.

X4 is also developing X4P-002, a CXCR4 antagonist that has unique properties that the company believes will enable penetration of the blood-brain barrier and provide appropriate therapeutic exposures to treat brain cancers, including glioblastoma multiforme (GBM).

Reporting to the Chief Financial Officer, the Director, New Product Planning will be responsible for designing and executing product and disease level strategies to advance Mavorixafor in WHIM Syndrome, cancers and other primary immune deficiency diseases. The candidate will join the X4 team in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in New Product Planning, Global Market Access, and early drug development who thrives in a team-oriented, fast-paced, and cross-disciplinary biotech environment. Prior experience in industry as commercial and/or market access lead required. Rare disease experience preferred.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

 

Scope of Work and Responsibilities:

  • Conduct rigorous market assessment(s) to define commercial development strategy for mavorixafor. Define overall commercial product strategic plan through phase 3 and beyond including life cycle management
  • Analyze target markets to determine current and future treatment paradigms, competitive landscape, unmet need, product positioning and value proposition
  • Act as commercial champion on program teams and lead commercial sub-teams to ensure that customer needs are incorporated into all development and life cycle management plans
  • Define and maintain a target product profile (TPP) and minimum product profile (MPP) to guide research discovery development go/ no go decisions
  • Build preliminary forecasting models to quantify market and product opportunities, including sensitivity analyses to validate key value-driven assumptions.  Maintain the revenue forecasts based on TPPs/MPPs for each program in development
  • Develop market access plans based on unique characteristics of target markets, and work with program teams to ensure appropriate clinical trial design to deliver data/endpoints required for reimbursement (market research, ad boards, etc.)
  • Drive early brand message development, including collaboration with public relations and medical affairs/medical communications (publication plans, continuing medical education/ congress activities)
  • In collaboration with internal advocacy partners, define and develop both professional and patient advocacy plans and establishing strong relationships with key stakeholders, including overseeing sponsorships
  • Develop and execute early life-cycle management initiatives, including follow-on indication analyses and global expansion opportunities
  • Oversee generic and brand naming initiatives for pipeline programs
  • Key partner in the evaluation of potential alliances for product candidates
  • Collaborate with Medical Affairs and Clinical to define therapeutic areas, therapeutic targets and technologies of interest.
  • Develop 1- and 5-year strategic commercialization plans for each product candidate
  • Collaborate with finance to put together annual commercial budget based on highest priority spend/activities for each candidate, enabling achievement of short- and long-term plans; manage budget for each program candidate
  • Ensure that coverage, reimbursement, pricing value evidence, and policy are integrated into the strategic plan that supports the overarching commercial position and links back to the clinical attributes of the candidate serving to advance X4’s knowledge and readiness for the global access environment
  • Work with leadership to create commercial launch build-out plan, resources and timelines that align with overall strategic plans for individual products
  • Build orphan drug market access and indication backgrounders for senior leadership and others in the organization as needed (other topics may also be required)

 

Qualifications and Professional Skills:

  • Bachelor’s Degree required with a minimum of 5-7 years in Ultra Rare/Rare Disease new products marketing/planning/launch and/or marketing research for early stage products role with a strong preference for biotechnology experience.
  • Orphan drug experience
  • Analytical expertise
  • Solid understanding of pharmaceutical development path from discovery to launch and ability to identify strategic and operational choices that could impact successful commercialization
  • Strong organizational and project management skills, ability to drive projects to completion in scientifically driven company
  • Established ability to work collaboratively across functions and maintain strong working relationships with key stakeholders
  • Strong written, verbal and presentation skills with all levels of an organization

 

 The above statements are intended to describe the general nature and level of work being performed.  They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce.  All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.   Please send your resume and cover letter to careers@x4pharma.com.  

Senior/Director Corporate Communications

Company Description:

Our grit drives our commitment to find solutions for patients. Every day, we strive to advance our pipeline of innovative medicines to treat rare diseases.

X4 was founded and is  led by an exceptional team with strong experience in research, development and commercialization of therapies to treat rare diseases, and is located in Cambridge, MA.

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4’s lead product candidate, Mavorixafor (X4P-001), has initiated  a Phase 3 trial in patients with a rare genetic PI called Warts, Hypogammaglobulinemia, Infections, and Myelokathexis, or WHIM syndrome. X4 has initiated a Phase 3 pivotal trial of Mavorixafor in patients with WHIM syndrome. In addition to the initial focus on WHIM syndrome, X4 believes that the biological rationale and available data on Mavorixafor support potential therapeutic benefits across a broad range of PIs, including Severe Congenital Neutropenia and certain lymphomas, such as Waldenstrom Macroglobulinemia.

X4 is also developing X4P-002, a CXCR4 antagonist that has unique properties that the company believes will enable penetration of the blood-brain barrier and provide appropriate therapeutic exposures to treat brain cancers, including glioblastoma multiforme (GBM).

 

Company Culture:

X4 is an innovative, global, publicly- traded company that offers strong growth potential and a stimulating environment. As a tight-knit team, we are dedicated high-achievers, and above all else, passionate about helping our patients. We take pride in our employee-focused atmosphere where each person’s contribution is vital to our success. People here are pro-active, enthusiastic about being given the opportunity to define, develop and shape the future of the company.

Employees thrive in this autonomous and fast-paced environment where success is based on contribution and work ethic, not on title or rank. Our leaders have open doors and employees are encouraged to make decisions, offer their opinions and get things done. Employees are empowered to think creatively, share ideas and are encouraged  to translate strategies into action.

X4 has built a reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions. 

 

What’s in it for you?

The Senior/Director, Corporate Communications will be accountable for strategic development and successful delivery of  external and internal  communications integrated with the company’s  presence in the public market, multi-media  outlets and the employee team.  Reporting to the CFO and working closely with the Senior Leaders you will develop and manage the  integrated communications plans including: investor relations,   public relations/affairs, crisis preparation, internal communications and communications directed at our patient community and patient advocates, all for a publicly-traded and fast-growing biotechnology company focused on rare disease.

Summary of role:

  • Develop and execute proactive strategies, programs and tactics to ensure the mission and unique voice of X4 is communicated to our investors, patients, external partners and employees.
  • Collaborate internally and externally to position X4 Pharmaceuticals as leader in biotechnology by communicating a unique message platform for differentiation
    • Align internal messages and communication strategies to support all communications across the organization and to the external community by working cross-functionally with finance, R&D/clinical, medical affairs, marketing, BD, HR, legal and regulatory.
  • Develop and execute strategies to increase company’s visibility and enhance its internal and external reputation to reach/attract key audiences including, but not limited to, investors, media, potential employees, KOLs, patients, advocacy groups, etc.
  • Support the CFO in building and maintaining relationships with print, digital/social and broadcast media in both business, and general news arenas, as well as with the buyside and sellside communities
    • Proactively identify, track and report on relevant industry and competitive news and corporate risks and measure results for informing strategic adjustments in messaging and positioning
  • Manage the development, content and delivery of press releases, investor databases, corporate mailing lists and annual reports, internet, corporate website, corporate presentations, positioning/white papers and other materials and strategies that influence market thinking and support achievement of business goals
    • Lead and partner with the external communications firm in developing strategies, plans and materials, as well as in executing IR/PR initiatives and proactive programs
    • Develop, implement and maintain appropriate metrics to evaluate impacts and effectiveness of all communications efforts
    • Develop/implement crisis communication plans; lead crisis/issue management programs for specific events or longer term, coordinating communication with all key stakeholders in a crisis situation
    • Actively develop and manage compliant social media as a key tool for outreach/awareness to the external community including patients, patient community groups, advocacy initiatives, etc.


Key competencies for success aligned with X4’s values:

Excellence: Do all things with rigor.

Accountability: Hold each other and ourselves accountable for our actions and to live our values.

Camaraderie: Work together as a team aligned to achieve our goals and be respectful of each other.

Integrity: Act with honesty and transparency.

Sense of Urgency: Demonstrate a higher sense of purpose: to alleviate human suffering and cure disease

Grit: Move forward with firmness of mind and unyielding courage.

 

What we need from you:

  • Bachelor’s degree required; MBA a plus, a minimum of 8-10 years of progressively responsible experience in a leading IR/PR communications company and/or complex Biotech/Biopharma company; working closely with Senior Leaders.
  • Demonstrated experience in developing comprehensive communications plans and strategies and building sustained external relationships with media and communications partners,
  • Respected and experienced at compliant engagement and communication with the Patient and Advocacy communities.
  • Dual talents of strong strategic abilities and a keen understanding of the role communications plays in helping the company achieve its strategic business objectives.
  • Developed and demonstrated sound strategic ability, good judgment and business acumen and has a high degree of passion and aptitude for creating and integrating the voice of the business externally and internally.
  • Ability to work in a fast-paced, ever-changing environment with all levels of employees in a team-oriented manner
  • Experience and ability to present often complex information in a clear, compelling and compliant manner to internal and external audiences
  • Strategic communications planner and a significant hands-on contributor, with superior writing and communications skills
  • Energetic self-starter; willing to take initiative with confidence and work effectively and with discretion in a rapidly changing, public company
  • Proven history as a creative, persuasive and diplomatic professional amongst colleagues and external colleagues
  • A proven team player, who thrives in a collaborative setting and possesses confident management style and leadership ability; evidence of discretion and tact in dealing with people and issues
  • A proven team player, who thrives in a collaborative setting and possesses confident style and leadership ability; proven evidence of discretion and tact in dealing with diverse issues and audiences.

 

The above statements are intended to describe the general nature and level of work being performed.  They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce.  All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.   Please send your resume and cover letter to careers@x4pharma.com

We invite you to apply for any of our current openings at careers@x4pharma.com for additional employment related information.

Location: Vienna, Austria

Scientist, Molecular and Cell Biology

About X4 Pharmaceuticals

Our commitment is to find solutions for patients. Every day, we strive to advance our pipeline of innovative medicines to treat rare diseases. Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer.

X4 Pharmaceuticals, Inc. was founded and is led by a team with deep product development and commercialization expertise, including several former members of the Genzyme leadership team and has its headquarter located in Cambridge, Massachusetts.

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Scientist – Molecular and Cell Biology.

 

Summary of the position:

The Scientist – Molecular and Cell Biology will establish and develop in vitro models of PIs and rare cancers, with focus on genotype-phenotype correlation. Main duties will be to:

  • Analyze genomic data to identify variants of specific target genes or pathways
  • Design, implement and develop in vitro assays to functionally and structurally characterize the gene variants identified, including protein-protein interaction studies, chemotaxis, Ca2+ flux, in various cell types
  • Develop high-throughput assays based on pilot studies
  • Structure, analyse and critically evaluate large sets of data
  • Present data at internal and external meetings
  • Write reports and scientific publications

 

Qualifications and skills:

  • PhD in Cell and Molecular Biology with at least two years of post-doctoral experience or corresponding biotech experience
  • Solid hands/on experience with molecular cloning, mammalian cell culture, transient and stable transfections
  • Extensive experience with flow cytometry, cell-based ELISA, chemotaxis, Ca2+ flux
  • In depth knowledge and experience working with GPCRs
  • Ability to supervise and train laboratory staff
  • Bioinformatics, gene set analysis (preferred but not required)
  • Genome editing (preferred but not required)
  • Previous work with CXCR4 and pathway genes (preferred but not required)
  • Experience with protein-protein interaction studies (preferred but not required)
  • Previous experience with BRET assays (preferred but not required)

 

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegial working environment
  • Opportunities for your personal development and to play a key role in a growing international research center
  • Opportunity to work at the interface of pre-clinical research and clinical translational science

 

In accordance with Austrian employment law, the minimum monthly gross salary for the position is EUR 3.348,82 which we are willing to adjust according to your qualifications, skills and expertise.

Please send your resume and cover letter in English to careers-vienna@x4pharma.com

Scientist, Immunology and In Vitro Models

About X4 Pharmaceuticals

Our commitment is to find solutions for patients. Every day, we strive to advance our pipeline of innovative medicines to treat rare diseases. Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer.

X4 Pharmaceuticals, Inc. was founded and is led by a team with deep product development and commercialization expertise, including several former members of the Genzyme leadership team and has its headquarter located in Cambridge, Massachusetts.

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Scientist – Immunology and In Vitro Models.

 

Summary of the position:

As part of our team, the Scientist – Immunology and In Vitro Models will

  • Perform research in the field of rare primary immunodeficiencies and cancer
  • Be responsible for the planning, coordination, documentation, and execution of laboratory experiments in the areas of immunology and cell biology
  • Establish novel cell based in-vitro and ex-vivo immune models, using (primary) human immune cells, for evaluation and mode of action studies of new therapeutics
  • Present data at internal and external meetings and extend knowledge by attending scientific conferences
  • Support the team in writing reports and manuscripts

 

Qualifications and skills:

  • PhD or Post Doc in immunology, molecular biology or a related discipline
  • Experience in the development of bioassays
  • Strong experience in mammalian cell culture including isolation and propagation of human and mouse immune cells
  • Hands-on experience in human and murine cellular immunology methods using primary and expanded immune cells (e.g. T cells, B cells, myeloid cells, co-culture assays and other primary cell assays)
  • Experience in analysis of proteins and cytokines by single and multiplex platforms
  • Experience in multi-color flow cytometry and fluorescence microscopy
  • Experience with DNA cloning and gene manipulation methods
  • Prior research experience in immunodeficiencies and or GPCRs is a plus
  • Clear ambition to learn about and implement new technologies and open to new challenges
  • Proficiency in data analysis and presentation tools
  • Proven ability to troubleshoot technical and scientific issues
  • Excellent oral and written communication skills in English
  • Collaborative team player attitude

 

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegial working environment
  • Opportunities for your personal development and to play a key role in a growing international research center

 

In accordance with Austrian employment law, the minimum monthly gross salary for the position is EUR 3.348,82 which we are willing to adjust according to your qualifications, skills and expertise.

Please send your resume and cover letter in English to careers-vienna@x4pharma.com

Technician, Molecular and Cell Biology

About X4 Pharmaceuticals

Our commitment is to find solutions for patients. Every day, we strive to advance our pipeline of innovative medicines to treat rare diseases. Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer.

X4 Pharmaceuticals, Inc. was founded and is led by a team with deep product development and commercialization expertise, including several former members of the Genzyme leadership team and has its headquarter located in Cambridge, Massachusetts.

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Technician – Molecular and Cell Biology.

 

Summary of the position:

The Technician – Molecular and Cell Biology will participate in developing in vitro models of primary immune deficiencies and rare cancers, with a focus on genotype-phenotype correlation. Main duties will mainly include:

  • Mammalian cell culture
  • Routine molecular biology techniques (PCR, cloning)
  • Flow cytometry, ELISA, WB
  • Cell based assays (chemotaxis, Ca2+ flux)
  • General lab support

 

Qualifications and skills:

  • Bachelor, Master, or PhD degree (or equivalent) with strong wet-lab experience
  • Extensive experience with mammalian cell culture, transfections, cell based ELISA, Flow cytometry and WB
  • Ability to draft routine reports and keep accurate records of work performed
  • High accuracy, reliability, precision under time pressure
  • Organizational skills and flexible mind-set
  • Previous work with GPCRs (preferred but not required)
  • Experience with protein-protein interaction studies (preferred but not required)

 

We are offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegial working environment
  • Opportunities for your personal development and to play a key role in a growing international research center

 

In accordance with Austrian employment law, the minimum monthly gross salary for the position is EUR 2.676,83 which we are willing to adjust according to your qualifications, skills and expertise.

Please send your resume and cover letter in English to careers-vienna@x4pharma.com

We invite you to apply for any of our current openings at careers-vienna@x4pharma.com for additional employment related information.

 

X4 Pharmaceuticals does not review or control the content on the website to which this hyperlink connects and this hyperlink does not constitute an endorsement by X4 Pharmaceuticals of the content of any non-X4 Pharmaceuticals website.

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