Careers

X4 offers a place where patient-focus is our priority and encourage people who share this value to apply. We offer a team-based approach in a collegial environment. We place a high importance on individual career development to enable one to meet his or her professional goals.

X4 is seeking key team members who:

  • Problem solve and who execute with high precision
  • Say what they mean, and let their words match their actions
  • Enjoy a team environment and foster direct and open communications

X4 is an equal opportunity employer and offers a comprehensive and competitive benefits package. Full-time employees are eligible for all benefits on their date of hire.

  • Health plan
  • Dental plan
  • Life/ADD insurance
  • Short- and long-term disability insurance
  • 401(k) plan for retirement savings
  • Subsidized parking or MBTA pass
  • Competitive Paid Time Off / Holidays

Open Positions

Location: Boston MA, USA

Senior Director, Drug Safety and Pharmacovigilance (DSPV)

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Chief Medical Officer, the Senior Director, Drug Safety & Pharmacovigilance (DSPV) is responsible for patient safety and pharmacovigilance activities, including maintenance of a quality system covering DSVP responsibilities, proper management of individual case safety reports, oversight of safety risk management activities including signal identification and assessment. In addition, this individual provides coordination of cross-functional activities related to risk management, proactively manages the benefit-risk profile for products in clinical development and pharmacovigilance activities for products at any stage in development and provides supervision of the activities of key external vendors for DSPV.

The Senior Director of DSPV at X4 plays a critical leadership role in product development across indications and throughout the life cycle. This requires close collaboration with Research, Pre-clinical Safety, Clinical Development, Medical Affairs, Regulatory Affairs, and other functions involved with product life-cycle management.

The successful candidate will have the required training and demonstrated expertise, accountability, and effectiveness leading DSPV activities for products in clinical development. The ability to work independently and collaboratively and to communicate effectively across the organization is essential. The individual who assumes this position will interact with multiple levels of management within X4, external stakeholders in the medical community, and global regulatory authorities.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

Scope of Work and Accountabilities:

  • Lead product safety surveillance and signaling activities in collaboration with DSPV vendors.
  • Develop and maintain a deep understanding of the safety profile for drug product and other development candidates that may enter clinical development, including a working knowledge of other products used in combination.
  • Lead and drive routine safety signaling activities, safety assessment and investigation are completed and documented in a timely manner, including all regulatory safety reporting and annual updates (DSUR).
  • Respond to product safety queries from all sources, including ethics committees and regulatory authorities.
  • Lead product benefit-risk assessment activities.
  • Confirm that the Safety Review Committee (SRC) is informed of patient safety concerns and that the recommendations of the SRC are carried out.
  • Lead Drug Safety and Pharmacovigilance representation in the assigned program team and clinical development team, and respective study management teams with critical roles
  • Provide strategic guidance for patient safety and product benefit-risk in clinical development
  • Responsible for safety content of program documents, including clinical protocols, investigator brochure and informed consent documents
  • Implement and establish processes for ongoing safety data review, including support of DSMBs.
  • Provide strategic and operational support for safety and benefit risk content of regulatory filing documents, including Clinical Study Reports, Common Technical Document and the Integrated Summary of Safety (ISS).
  • Oversee and develop the content of aggregate safety reports (i.e., DSUR, PSUR), including assessment of benefit-risk.
  • Create the company product level Development Risk Management Document (DRMP).
  • Responsible for the content of a Risk Management Plan or REMS if required.
  • Provides guidance on the design of post-approval safety studies if required.
  • Develop and establish a high level of trust and collaboration with cross-functional counterparts and external vendors on carrying out DSPV activities.
  • Committed to accurate and timely completion and reporting of periodic and expedited safety reports, in compliance with internal timeframes and timeframes dictated by regulatory authorities.
  • Developing and updating as needed the strategy for the DSPV group.
  • Maintaining and growing as needed the resourcing of the DSPV group either by outsourcing or hiring.
  • Build, manage and oversee goal setting, performance, and career development of all full-time employees of the DSPV group.
  • Partner collaboratively with the Medical Director(s) overseeing the safety monitoring activities for ongoing and completed clinical trials.
  • Author and/or contribute to the safety sections of clinical study reports, IND and NDA filings, publications, briefing books and any other documents related to drug development programs.
  • Other job duties may be assigned according to business needs.

Qualifications and Professional Experience:

  • MD or PhD or similar degree in medicine, pharmacy, epidemiology, or relevant scientific disciplines.
  • Minimum of 7-years of experience in drug safety and pharmacovigilance in the pharmaceutical industry.
  • Background in drug Drug Safety/PV for rare diseases.
  • Prior experience in DSPV in the pharmaceutical industry is required.
  • Demonstrated strategic and critical thinking skills.
  • Proven experience in performing effectively in a matrixed and dynamic environment. Ability to lead and collaborate within a complex organization, across functions and geographies, to work in an entrepreneurial culture.
  • Extensive knowledge of DSPV requirements and regulations for drug development with FDA and EMA.
  • Demonstrated sense of urgency and accountability for DSPV activities.
  • High EQ with a passion for drug safety and collaboration within the department and across multiple functions.

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Director, Regulatory CMC

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Vice President, Regulatory Affairs, the Director, Regulatory CMC will be responsible for designing and implementing global regulatory CMC strategies consistent with the applicable requirements and coordinating all aspects of CMC regulatory agency interactions and submissions for the assigned programs. This position will report to the Vice President, who oversees the entire function of Regulatory Affairs.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

Scope of Work and Accountabilities:

  • Serve as product lead for all CMC regulatory strategies and execution, assess risks and recommend mitigation options in partnership with cross functional internal stakeholders.
  • Lead and drive meetings with regulatory agencies for all CMC-related matters. These include development and submission of meeting materials, i.e., meeting request, meeting package, and presentation; ensure team preparedness and response, etc.
  • Provide strategic CMC regulatory guidance for global development and registration programs (i.e., IND, CTA, NDA, MAA), working closely within the CMC teams to plan, integrate and align global expectations for development and commercialization.
  • Manage timelines & lead the compilation, review, and approval process of CMC documents intended for regulatory submission.
  • Oversee CMC submissions, such as IND/IMPD and marketing application sections, including responses to regulatory agency requests for information, working collaboratively with subject matter experts in CMC Tech OPS, QA, global supply chain and other functions as needed.
  • Assess and communicate CMC regulatory requirements to ensure all development activities are compliant with applicable global regulations and guidelines.
  • Guide and ensure compliance with all CMC reporting requirements, including managing the CMC change control process, tracking global regulatory commitments, and annual reports.
  • Own and oversee the management of all consultants, contract staff and vendors, as needed to support regulatory activities
  • Keep abreast of new ICH, FDA, EMA, PMDA regulatory requirements, as well as those from other key International regulatory authorities.
  • Act as the principal CMC, RA liaison with the FDA for original product approvals, maintenance, and negotiations.

Qualifications and Professional Experience:

  • MS or BS degree in a scientific discipline with 10+ years of pharmaceutical development experience, including 7+ years of direct regulatory-CMC experience with demonstrated leadership skills
  • Experience leading and driving successful regulatory submissions, with first-hand knowledge of and experience interacting with FDA and European authorities at centralized or national level
  • Excellent regulatory writing skills and ability to critically review regulatory documents
  • Profound experience and knowledge of US regulations and ICH Q guidance, principles, concepts, industry practices and standards.
  • Deep expertise and understanding of the CMC disciplines, technical development and manufacturing, quality and supply chain and experience working on CMC Teams.
  • Successful history working collaboratively across departments.
  • Strong attention to detail with an ability to understand the broader picture and priorities.
  • Effective working individually and aligning within a multi-disciplinary team, as well as with external partners and vendors.

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Director, Regulatory Affairs

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Vice President, Regulatory Affairs, the Director, Regulatory Affairs will be responsible for designing and overseeing the execution of regulatory strategy to advance regulatory registration of current and future pipeline assets. This position works with a high level of autonomy, has a high degree of latitude to manage workload, takes the initiative and defines direction with limited supervision. In addition, he/she will act as a subject matter expert in a matrix team environment, motivates self and others to complete projects on time and deliver high-quality business results for the programs and organization.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

Scope of Work and Accountabilities:

  • Lead and drive the preparation, internal communication and alignment, and implementation of regulatory strategies with direct accountability for the US, Europe and other geographies, as needed, to meet the corporate objectives for the assigned asset(s).
  • Identify potential regulatory risks associated with the strategic and operational plans and propose options to mitigate them.
  • In partnership with the Vice President of Regulatory Affairs, act as a point of contact with the FDA, interact directly or indirectly with ex-US Health Authorities, and manage consultant teams assisting the regulatory efforts
  • Lead and participate in the planning, preparation and delivery of information packages supporting regulatory submissions throughout the asset’s life-cycle, including but not limited to briefing documents, INDs and CTAs and associated amendments, NDA/BLA, MAA, regulatory obligations (e.g., orphan drug annual report), etc.
  • Represent the Company at meetings with Regulatory Authorities
  • Provide regulatory affairs representation on cross-functional project teams and be an active and strategic partner contributing to the advancement of the regulatory and scientific objectives of the assets in scope
  • Monitor changes in regulatory requirements and emergence of new regulations; insightfully assess their potential impact on current asset strategy and corporate objectives to educate and inform project team(s) and leadership decisions
  • Provide regulatory assessment to assist business development during due diligence activities

Qualifications and Professional Experience:

  • Bachelor’s degree required, ideally in a science-related field; advanced degree, e.g., Ph.D., preferred
  • A minimum of 10 years in the biotechnology and/or biopharmaceutical industry
  • Minimum 7 years in a Regulatory capacity with experience in several therapeutic areas, preferably through commercialization. Experience in Rare Disease is highly valuable.
  • Preferred candidates will have experience working as a lead in Regulatory Affairs across two or more major geographic areas and prior experience with small molecules and/or biologics
  • Deep knowledge of regulatory guidelines required to lead the overall regulatory strategy
  • Demonstrated experience interacting with the US FDA, EU, EMA, and other regulatory agencies
  • Proven leadership experience in the submission and regulatory maintenance of INDs, CTAs, NDAs/BLAs or MAAs
  • Known reputation for integrity professionalism.
  • Expertise in all phases of drug development, including Regulatory experience implementing the life cycle of a product from Phase III to commercialization in several therapeutic areas
  • Excellent oral and written communication skills.

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Vice President, Preclinical Development & Toxicology

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Chief Scientific Officer, the Vice President, Preclinical Development & Toxicology will be responsible for preclinical development and nonclinical safety studies to support the advancement of X4 molecules for clinical evaluation in humans. He/She will be responsible and accountable for the design and execution of all preclinical development and non-clinical safety studies of pipeline compounds as well as compounds currently in human clinical trials. The successful candidate will oversee all related external activities conducted at CROs to ensure the successful delivery of study results and reports consistent with project timelines. Additionally, he/she will lead and be accountable for the preparation of non-clinical pharmacology and toxicology reports, as well as summaries to support Regulatory filings.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

Scope of Work and Accountabilities:

  • In partnership with the CSO, develop strategies and execute on the Company vision to advance first-in- class and best-in-class molecules through pre-clinical and clinical development supported by appropriate pre-clinical and non-clinical safety study results
  • Oversee pre-clinical development and nonclinical safety studies for X4’s small molecule products from the discovery stage through clinical development
  • Responsible for the pre-clinical and clinical safety sections of regulatory filings and for leading these functions to prepare documents in partnership with X4 Regulatory for regulatory agencies.
  • Develop and oversee the execution of phase appropriate nonclinical safety strategies along with integrated project plans including milestones, timelines, resources, and budgets.
  • Provide strategic contribution as the subject matter expert for GLP, non-GLP, and safety pharmacology studies.
  • Liaise and represent the company as the nonclinical safety expert before U.S. and European regulatory authorities
  • Drives and is accountable for delivering audited and timely delivery of high-quality safety reports to enable clinical plans and regulatory filing submissions in multiple markets.
  • Identify, lead, manage, and build a long-term relationship with CROs to conduct preclinical development activities and nonclinical safety studies for pharmaceutical candidates.
  • Reviews and provides expertise for all safety associated regulatory and quality documents associated with INDs, NDAs and other regulatory submissions and documentation
  • Creates the standard for compliance to meet and exceed regulatory requirements both internally and externally by ensuring CROs are using systems and processes in compliance with all relevant regulatory standards.
  • Serve as the preclinical development and toxicology representative at all cross-functional meetings both internally and externally
  • Responsible for forecasting and managing preclinical development and nonclinical safety program investment plans that align with business goals
  • Proactively manages risk and drives project-related decisions to ensure teams successfully achieve their goals and team milestones.

Qualifications and Professional Experience:

  • PhD in Pharmacology, Biology, Toxicology, or related scientific discipline
  • 10+ years of experience in a pharmaceutical or biotechnology management of nonclinical safety activities for discovery and development programs and overseeing preclinical development studies of discovery candidates
  • In-depth understanding of all aspects of nonclinical safety and experience with regulatory filings
  • Extensive knowledge of relevant FDA and EMEA regulations and processes
  • Demonstrated proven experience in working with and managing the US and International CROs for protocol design and study execution
  • Ability to operate effectively within an entrepreneurial and science-driven company environment; self-motivated, delivery-oriented, assertive, able to inspire others, driven and hands-on with unquestionable integrity and the highest ethical standards.
  • Leadership experience with managing teams, budgets to enhance business objectives

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

HR Specialist

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Senior Vice President, Human Resources, the HR Specialist will work closely and regularly with hiring managers, internal stakeholders, and external partners. The position will support the execution of best-in-class candidate and employee experiences through a commitment to the Company Values and priorities, including respect for all, integrity, accountability, sense of urgency, transparency, and attention to detail. This individual must demonstrate the ability to work independently yet collaboratively, with a validated assurance that they will represent X4 Pharmaceuticals in all internal and external interactions in an unwavering professional manner.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

Scope of Work and Accountabilities:

  • Develop as an HR professional and serve as support in all Human Resource activities in a publicly-traded biotech company focused on rare disease, with a strong focus on talent acquisition, the candidate experience and other innovative programs supporting our values-driven culture.
  • Serve as a strong role model embracing professionalism, discretion, attention to detail, and a commitment to customer service.
  • Support high-touch Talent Acquisition efforts as a champion of an excellent candidate experience. Responsibilities include interview coordination and scheduling, thoughtful engagement with a diverse range of candidates, internal communications with all levels of management, compliant and accurate confidential data record management, and utilization of the Company’s Applicant Tracking System.
  • Anticipate and proactively communicate candidate activity and status to HR colleagues, hiring managers and external partners
  • Manage and participate in the Company’s New Employee Orientation (NEO). That includes working cross-functionally to ensure the information in the NEO presentation is current and relevant.
  • Serve as an administrator of the ATS system, including maintaining recruiting details, optimizing the tool to maximize all capabilities with precision, and meeting compliance requirements.
  • Responsible for collecting accurate and timely data and summarizing quarterly metrics for the SVP, HR for Board and Leadership presentations.
  • May work with the HR team and external consultants to support and coordinate initiatives related to employment branding, employee engagement, learning and development and teambuilding.
  • Bring creativity and an eye for timing and detail to support and coordinate Employee Engagement Activities, Recognition and Rewards, and Company Events
  • As a face of the Company, serve as liaison to steer internal and external questions to the right resource.

Qualifications and Professional Experience:

  • Minimum Bachelor’s degree
  • Minimum 2 years of relevant Human Resources and/or Talent Acquisition working in a full-service Human Resource department where the core values and employees are the Company’s priority.
  • Biotech/Biopharma experience industry strongly preferred, experience working in a publicly-traded company also preferred
  • Reputation for successful business interactions and resourceful problem solving at all levels of the organization and with a diverse group of external partners.
  • Highly skilled and adaptable with technology, data collection, accuracy and expertise working with MS Suite. Strong experience designing PowerPoint presentations and excel.
  • Experience in a high-growth, entrepreneurial environment that requires adaptability, resourcefulness, attention to detail, and strong organization and prioritization. Behaviors drive successful results.
  • Intellectual curiosity and interest in building a career in Human Resources.
  • Highly developed communication skills and awareness of the difference between verbal, written and electronic messaging.
  • A passion for working in a company where the needs of our patients drive our daily living.

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Director, GMP Quality Operations

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Vice President, Quality, the Director, GMP Quality Operations will lead and drive the GMP Quality Operations related activities at X4 Pharma. This role will represent Quality on CMC teams for all X4 programs. It will partner internally with Quality Systems, Analytical Development, Process and Product Development, CMC Leadership and Supply Chain functions to ensure clinical supply, support commercialization of X4 products, and develop and implement phase-appropriate quality systems. The incumbent will foster strong relationships with external partners to build a quality-focused, efficient and collaborative culture to meet department and company goals.

The incumbent will ensure high-quality execution of manufacturing and supply chain operations for clinical products and establish readiness for commercial marketing authorization and launch. The role requires championing and driving multiple workstreams.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

Scope of Work and Accountabilities:

  • Lead the Manufacturing and Supply Chain Quality function within the Quality department to meet organizational goals and objectives
  • Participate in the effective quality oversight of cGMP activities at X4 and its external manufacturing and testing partners for clinical stage products
  • Shape and drive Quality culture, fostering a proactive, phase appropriate quality-focused approach
  • Improve existing and develop/implement new GMP processes in partnership with Quality Systems and Technical Operations for product commercialization in compliance with applicable regulation
  • Partner and provide oversight and guidance on GMP compliance matters within CMC teams
  • Develop, implement and execute a risk-based audit strategy for GMP Vendors
  • Lead and manage GMP audits, including oversight of consultant mediated and/or self-conducted Vendor Qualification audits
  • Assist and advise in the development of CAPA plans in response to audits/inspections and review and follow-up of all audit CAPAs
  • Establish and maintain Quality Agreements with Vendors
  • Ensure products for human use are manufactured in compliance with the applicable requirements, regulations and guidance and meet appropriate quality specifications and standards
  • Provide day-to-day quality and compliance support, including issue management (triage/investigation/actions), batch record review, lot disposition, change controls etc.
  • Provide and drive training sessions and mentor top-performing teams on topics related to GMP quality and global regulations
  • Partner with key internal and external partners to champion prospective Inspection Readiness
  • Periodically report the state of GMP Quality and compliance to X4 Senior Management
  • Establish a strong interface with the external development and manufacturing partners while building strong relationships and fostering continuous improvement
  • Support all product development and commercialization related activities, including process performance qualification, submission of regulatory filings, and product launch

Qualifications and Professional Experience:

  • BS or MS in engineering or life sciences technical discipline
  • Minimum 12 years of relevant industry experience in Quality Assurance, including management of virtual manufacturing and distribution supply chain
  • Experience with rare disease products is a plus
  • Knowledge and understanding of ICH Guidelines and FDA and EU Requirements
  • In-depth knowledge and understanding of Data Integrity requirements
  • Direct experience in managing Health Authority GMP Inspections is highly preferred.
  • Proven experience with developing strong partnerships with cross functional senior key stakeholders to ensure that strategic business goals are met through the sharing of knowledge and teamwork
  • Demonstrated experience with content ownership, delivery and strategic thinking
  • Proven effective time management skills, ability to work independently and in a team environment that drives business needs forward
  • Must be willing to travel domestically and internationally up to 25%

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Senior Director / Vice President, Corporate Communications & Investor Relations

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Chief Financial Officer, the Senior Director / Vice President, Corporate Communications & Investor Relations will be responsible for strategic and operational leadership of all company communications. He/She will lead our external investor strategies and manage external and internal communications, ensuring consistent messaging across all platforms to all stakeholders, both internal and external. He/She will also lead the development, implementation, and management of a comprehensive investor relations and corporate communications strategy and manage relationships with the investment community, including investors and sell-side analysts. This individual will also be responsible for all corporate communications, including corporate visibility, media and public relations, alignment with corporate strategy and public affairs. Other aspects of the position will include contributing to the company’s branding, employer branding and internal messaging strategy and execution. This position will require developing a strong business relationship and collaborating with the executive team, along with all internal functional leads as well as human resources.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

Scope of Work and Accountabilities:

  • Lead and implement the strategic planning, direction, and execution of all Investor Relations, Public Relations, and Corporate Communications for the organization
  • Develop, oversee, and drive a strategic and comprehensive investor relations plan to align with the overall business objectives.
  • Partner with the CEO and CFO to lead and manage the company’s participation on quarterly earnings calls, investment conference calls and in-house meetings, roadshows, analyst days, and one-on-one meetings.
  • Develop and lead all strategic communications including, developing communication plans to take advantage of key company milestones, preparing press releases, presentation decks, and earnings releases. Creating management Q&As, conference call scripts, and business descriptions/other information for securities filings, the annual report, and the company website
  • Interact across the organization to target, surface, and generate awareness around potential news flow and monitor/manage via a knowledge map document and related internal communications meetings.
  • Coordinate, plan and execute key company events, including analyst days, medical conferences, data presentations and other related news-driven opportunities.
  • Build strong relationships and maintain regular communication with individual investors. Select sell-side contacts to provide up-to-date information about events and market trends affecting the company to communicate our long-term vision.
  • Collaborate and coordinate with other functional areas to develop messaging that authentically promotes the company internally and externally.
  • In partnership with Human Resources, functional leads, general counsel, and corporate counsel, manage internal employee communications and media training, including managing town halls and certain internal company meetings.
  • Develop and evolve the communication strategy to align with changes to the business.
  • Confirm and verify all information is following product promotion guidelines, SEC regulations and adheres to Regulation Fair Disclosure
  • Lead and develop strong partnerships with external firms and consultants, including digital /social media firms, to ensure projects are delivered on time and within budget.

Qualifications and Professional Experience:

  • 10+ years in the biotech /pharmaceutical industry, with direct experience leading investor relations and corporate communications within a publicly traded biotech company
  • Bachelor’s degree required; Master’s degree preferred in a related discipline.
  • Reputation for successful business interactions, established relationships and credibility with the investment community, media, and biopharma journalists.
  • Ability to maintain confidentiality, exercise sound judgment and the highest level of discretion; knowledge of SEC and disclosure requirements preferred.
  • Exceptionally strong verbal, written and digital communication skills, including the robust ability to present clearly and concisely both scientifically and technically to various audiences.
  • Deep knowledge and experience with managing and overseeing contract IR/PR agencies and vendors.
  • Proven experience developing strong partnerships with cross-functional senior key stakeholders to ensure that strategic business goals are met through the sharing of knowledge and teamwork.

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Senior Director, Information Technology

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Vice President, Finance & Corporate Controller, the Senior Director, Information Technology will oversee all aspects of information technology, including strategy, operations, security, governance, and policies and risk assessment. He/she will be expected to develop an information technology and security vision/strategy that will support and align with the organizational priorities. Furthermore, support business capabilities that ensure technology architecture and governance align with strategic business initiatives. He/she will be a strong, motivated leader who has demonstrated success driving business transformation within a fast-paced, publicly traded organization.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

Scope of Work and Accountabilities:

  • Develop and implement a strategic roadmap for IT, including network infrastructure, computing hardware, business software, cyber and data security.
  • Oversee all technology operations and evaluate them according to the overall corporate growth plans.
  • Lead and develop IT financial budgets and forecasts to ensure IT projects are delivered on time and within budget.
  • Drive disciplined investment decisions, including using total cost of ownership and return on investment analysis to help prioritize the portfolio of projects.
  • Build and manage a team of IT professionals and vendors to execute projects and provide daily IT operations support to the business as it prepares for commercialization.
  • Evaluate and determine a balance between insourced and outsourced IT service models.
  • Oversee security awareness training program for all employees, contractors, and approved system users, and establish metrics to measure the effectiveness of this security training program for different audiences.
  • Identify and interact with functional areas to ensure consistent application of policies and standards across all technology projects, systems, and services, including privacy, risk management, compliance, and business continuity management.
  • Establish and support IT general controls and ensure compliance with industry best practices, SOX, Part 11, and other relevant regulatory requirements.
  • Provide clear risk mitigating directives for projects with components in IT, including the mandatory application of controls.
  • Lead the information security function across the company to ensure consistent and high-quality information security management to support the business goals.
  • Oversight of GDPR compliance, Cybersecurity procedures, business continuity, disaster recovery, IT change management/controls, and IT policy and procedures.

Qualifications and Professional Experience:

  •  Bachelor’s degree in Computer Science or Related Field
  • 10+ years of experience, including management experience, in a fast-paced organization, preferably within a commercial Biotech/Biopharmaceutical company
  • Experience in a publicly-traded company required.
  • Deep knowledge and expertise in project management with a proven track record to plan, execute and deliver projects on time and within budget.
  • Ability to exercise discretion in handling confidential material and information.
  • Proven experience with developing resilient internal/external partnerships to ensure that strategic business goals are met through the sharing of knowledge and teamwork.
  • Ability to manage multiple activities simultaneously and prioritize effectively.
  • In-depth experience managing SOX-compliant technology environments and systems preferred.
  • Demonstrated ability to manage business systems software projects, including defining, planning, and executing predictable schedules, cost estimates, and required quality.
  • Deep knowledge and understanding of selection, deployment, and management of business tools such as ERP, CRM, and other systems.
  • Well-respected reputation for integrity, discretion, and sound judgment

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

Director, Financial Planning & Analysis

Company Description:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (PIs) and cancer. A number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome, and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

Reporting to the Vice President, Finance, the Director of Financial Planning and Analysis will be responsible for leading the Financial Planning and Analysis function of the organization. You will drive the process, infrastructure, and execution of forward-thinking and analytics-based activities that assist in decision-making to ensure they align with corporate goals and maximize value to the business. The position requires professionalism and discretion, the ability to multi-task while delivering high-quality work, and the capability to work effectively in a rapidly changing environment. This is a highly visible role that will serve as a business partner to senior leadership and support the Board of Directors and other executive leaders. The role requires being a strong cross-function collaborator, an outstanding communicator, and a strategic thinker.

To succeed at X4, the candidate will have a sustained reputation for putting the patient first and foremost, as well as a values-driven work style where integrity and grit drive all behaviors, decisions and actions.

This position is located in Allston, MA. and does not include a relocation package. Qualified out-of-state applicants are responsible for their relocation.

Scope of Work and Accountabilities:

  • Lead the creation of the budget process, including – developing, communicating, and driving the budget timeline, creating budget templates, creating/maintaining budget roll-up files, preparing budget deliverables
  • Monitor and interpret analyst models to provide visibility to senior leadership on variation from current modeling
  • Develop long-range plans and short-term forecasts with senior leadership that focus on understanding activities and cost drivers
  • Create high-quality variance and trend analysis monthly, quarterly, and annually for budgeting and forecasting.
  • Provide senior leaders with financial analysis to drive decision making by developing an in-depth understanding of key drivers
  • Analyze complex financial information and reports to provide accurate and timely financial recommendations to management for decision-making purposes
  • Partner with the Accounting team for month-end and quarter-end close reporting
  • Support Senior Management Team and department heads with in-depth analysis to communicate key business trends and highlight key opportunities
  • Prepare concise ad-hoc presentations to Board of Directors and Senior Management Team to provide critical insights on the strategic initiatives
  • Assist in implementation and administration of FP&A tools and systems that provide robust planning and reporting capabilities
  • Special projects and other tasks as assigned

Qualifications and Professional Experience:

  • Bachelor’s degree in Accounting or Finance required; MBA preferred
  • Over seven years of experience in financial planning within the life science/biotech industry
  • Experience in a life science commercial stage company
  • Excellent analytical, decision-making, and project management abilities
  • Advanced modeling experience
  • Strong expertise with ERP & EPM systems, experience with NetSuite a plus
  • High proficiency with Microsoft Office suite (PowerPoint, Excel, and Word)
  • Ability to manage competing priorities to meet deadlines
  • Demonstrates a sense of urgency, proactive thinking, and productivity in a fast-paced, entrepreneurial, and team-oriented environment
  • Exceptional written and verbal communication skills and translating ideas into clear, high impact communications
  • Previous experience in a high growth or start up environment a plus

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law. Please send your resume and cover letter to careers@x4pharma.com.

We invite you to apply for any of our current openings at careers@x4pharma.com for additional employment related information.

Location: Vienna, Austria

Privacy Notice for applications of X4 Pharmaceuticals (Austria) GmbH in accordance with Article 13 of the General Data Protection Regulation (“GDPR”)
Scientist – Translational Sciences

About X4 Pharmaceuticals: 

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on the Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Scientist – Translational Sciences.

Summary of the Position:

We are looking for an experienced and highly motivated Scientist – Translational Sciences with a strong background in translational research and discovery including pharmacological and disease animal models as well as assays with clinical/human specimens for the mechanistic characterization of new therapies. The successful candidate will contribute to the identification, validation and characterization of novel targets and therapeutics, with a focus on primary immunodeficiencies and cancers as well as new indications including neurodegeneration. Reporting to the Senior Director, Translational Sciences, the main duties will include:

  • Work with an established team of Research Associates within the Translational Sciences Department
  • Collaborate with internal and external research teams and CROs to advance our translational research capabilities
  • Contribute to the identification and validation as well as project development processes for new therapeutic targets and indications
  • Select and perform pharmacological and efficacy studies in relevant animal models within a variety of therapeutic areas
  • Develop and execute on in vitro assays including biomarker studies to support clinical trials and mode-of-action studies of our compounds
  • Analyze and present data at internal and external meetings
  • Write reports and scientific publications

Qualifications and Skills:

  • PhD degree in relevant field (e.g. B and T cell immunology, oncology, hematology, neurobiology or cell biology)
  • Minimum of four years of post-doctoral and wet lab experience or corresponding industrial experience
  • Expertise in pharmacology and disease animal models
  • Strength in research and interpretation of large datasets and cross-functional studies in various disease indications
  • Extensive experience and trouble-shooting skills in relevant molecular biology techniques
  • Experience working within a Biosafety Level 2 laboratory including work with bacterial/viral pathogens and patient material as well as analysis and interpretation of sophisticated sequencing methods (e.g. scRNAseq), transcriptomics and/or proteomics in an advantage
  • Effective communication and relationship building skills with internal and external stakeholders
  • Independent, proactive, and hands-on team player with strategic thinking and sense of urgency
  • Ability to supervise and train laboratory staff

We are Offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegial working environment
  • Opportunities for your personal and career development and to play a key role in a growing international research center
  • Opportunity to work at the interface of pre-clinical research and clinical translational science

In accordance with Austrian employment law, the minimum gross salary p.a. for the position is EUR 48.690,60 which we will adjust according to your qualifications, skills and expertise.

Please send your cover letter referring to the position “Scientist – Translational Sciences” and resume specifying your scientific expertise and technical skills in bullet point format in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

Research Associate – Translational Sciences

Fixed-Term, 18 months

About X4 Pharmaceuticals:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on the Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a fixed-term for 18 months, full-time employment contract for a Research Associate –Translational Sciences.

Summary of the Position:

We are looking for an experienced and highly motivated Research Associate – Translational Sciences with a strong background in immunology (B, T, monocytic, macrophage and NK cells) to support the development of in vitro assays and sample analyses of our translational in vivo research in primary immune deficiencies, cancers and neurodegeneration as well as new indications. Reporting to a scientist, the main duties will include:

  • Immune and/or neuronal cell research and establishment of new molecular biology techniques and protocols
  • Mammalian cell culture
  • Multi-colour flow cytometry, ELISA, WB, ELISpot and microscopy
  • Cell-based functional assays (migration, differentiation)
  • Routine molecular biology techniques (PCR, cloning)
  • Sample management and handling in a biosafety level 2 (BSL2) laboratory setting
  • General lab support

Qualifications and Skills:

  • PhD in relevant field (e.g. cellular immunology, oncology, neurodegeneration, hematology), or Master degree with a minimum of 4 years of relevant research experience
  • Extensive experience with mammalian cell culture, cell-based assays, multi-colour flow cytometry including intracellular (cytokine) staining, serology, ELISA, WB and ELISpot
  • Experience working with bacterial/viral pathogens and patient samples in functional assays and BSL2 is an advantage
  • Ability to draft routine reports and keep accurate records of work performed
  • High accuracy, reliability, precision with sense of urgency
  • Organizational skills and flexible mind-set

We are Offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegiate working environment
  • Opportunities for your personal and career development and to play a key role in a growing international research center

In accordance with Austrian employment law, the minimum gross salary p.a. for the position is EUR 38.920,00 which we will adjust according to your qualifications, skills and expertise.

Please send your cover letter referring to the position “Research Associate – Translational Sciences” and resume specifying your technical skills in bullet point format in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

Research Assistant - Discovery Department

About X4 Pharmaceuticals:

X4 is focused on restoring healthy immune system function by developing novel therapeutics for the treatment of rare diseases.

Our first-in-class, oral, small molecule therapeutics are antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including Inborn Errors of Immunity (IEI) and cancer. A number of IEI are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12.

X4 Pharmaceutical’s lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, once-daily, oral inhibitor of CXCR4, currently in a Phase 3 clinical trial for the treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. Mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and a favorable safety profile. Mavorixafor was recently granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with WHIM syndrome and was granted orphan drug status by the FDA in 2018 and by the European Commission in 2019 for the treatment of WHIM syndrome.

Mavorixafor is also being developed by X4 to treat Severe Congenital Neutropenia (SCN), Waldenström’s macroglobulinemia (WM), and clear cell renal cell carcinoma (ccRCC).

X4’s research and development facility in Vienna, Austria, X4 Pharmaceuticals (Austria) GmbH is located on the Campus Vienna Biocenter (Helmut-Qualtinger-Gasse 2, 1030 Vienna) and is run by a team of highly motivated scientists and technicians who are dedicated to build a Center of Research Excellence in the field of small molecule therapeutics. X4 Pharmaceuticals (Austria) GmbH is currently offering a full-time employment contract for a Research Assistant – Discovery Department.

Summary of the Position:

The Research Assistant – Discovery Department will participate in developing in vitro models in immunology, oncology and neurology, with a main focus on primary immune deficiencies and genotype-phenotype correlation. Reporting to a scientist, main duties will include:

  • Mammalian cell culture
  • Routine molecular biology techniques (PCR, cloning)
  • Generation of stable cell lines
  • Flow cytometry, ELISA, WB, microscopy
  • Develop and perform cell-based assays to support therapeutic areas of interest (migration, differentiation)
  • General lab support

Qualifications and Skills:

  • Bachelor, Master or equivalent with strong wet-lab experience
  • Extensive experience with mammalian cell culture, transfections, cell-based ELISA, Flow cytometry and WB preferably in the field of oncology, neurology and/or immunology
  • Experience with human iPSC or ESC culturing and differentiation (preferred but not required)
  • Experienced in hematopoietic cell culture (preferred but not required)
  • Experience with genetic engineering, CRISPR/Cas (preferred but not required)
  • Ability to draft routine reports and keep accurate records of work performed
  • High accuracy, reliability, precision under time pressure
  • Organizational skills and flexible mind-set

We are Offering:

  • A strong, dedicated and multinational team of scientists and technicians
  • An open, transparent and collegiate working environment
  • Opportunities for your personal and s and to play a key role in a growing international research center

In accordance with Austrian employment law, the minimum gross salary p.a. for the position is EUR 34.140,40 which we will adjust according to your qualifications, skills and expertise.

Please send your cover letter referring to the position “Research Assistant – Discovery Department” and resume specifying your technical skills in bullet point format in English to careers-vienna@x4pharma.com

Please read our X4 Pharmaceuticals (Austria) GmbH Privacy Notice for Applicants, which you will find on our website by following this link: https://www.x4pharma.com/careers/

We invite you to apply for any of our current openings at careers-vienna@x4pharma.com for additional employment related information.

 

X4 Pharmaceuticals does not review or control the content on the website to which this hyperlink connects and this hyperlink does not constitute an endorsement by X4 Pharmaceuticals of the content of any non-X4 Pharmaceuticals website.

Continue