Progress
At X4, we are driven to successfully advance innovative therapeutics that truly make a difference in the lives of people with rare immunodeficiencies and few or no treatment options.
What’s it Like Living with Chronic Neutropenia?
![kevin-video-thumb Kevin Knapp](https://www.x4pharma.com/wp-content/uploads/2022/12/kevin-video-thumb.jpg)
Kevin’s Story
![vanessa-video-thumb Vanessa](https://www.x4pharma.com/wp-content/uploads/2022/12/vanessa-video-thumb.jpg)
Vanessa’s Story
What’s it Like Living with WHIM Syndrome?
![Grabrielle-willow Click to hear Gabrielle's Story](https://www.x4pharma.com/wp-content/uploads/2024/03/Grabrielle-willow.jpg)
Gaby & Willow
![courtney-thumbnail Click to hear Courtney's Story](https://www.x4pharma.com/wp-content/uploads/2024/03/courtney-thumbnail.jpg)
Courtney’s Story
Our Clinical Trials
Chronic Neutropenic Disorders
- Chronic neutropenia is a rare blood condition defined by a decrease in blood neutrophil counts lasting more than three months; people with chronic neutropenia are at higher risk of developing infections and certain cancers and having a reduced quality of life.
- Following successful completion of Phase 1b and Phase 2 clinical trials exploring the use of once-daily oral mavorixafor in the treatment of certain chronic neutropenic disorders, we have initiated a pivotal, global Phase 3 clinical trial.
- The Phase 3 4WARD trial (NCT06056297) aims to evaluate the efficacy, safety, and tolerability of oral once-daily mavorixafor (with or without G-CSF) in people with congenital or acquired primary autoimmune and idiopathic chronic neutropenia who are experiencing recurrent and/or serious infections. For more information, please visit 4WARDstudy.com.
Community and Care Resources
Private Facebook group for people living with WHIM Syndrome. Search under Groups for WHIM Syndrome Community
![Facebook_f_logo Facebook](https://www.x4pharma.com/wp-content/uploads/2024/03/Facebook_f_logo.png)
![IDF logo Immune Deficiency Foundation](https://www.x4pharma.com/wp-content/uploads/2024/03/IDF-logo.png)
The Immune Deficiency Foundation (IDF)
Not-for-profit patient advocacy organization that provides information and resources for people with primary immunodeficiencies (PIs)
International Patient Organization for Primary Immunodeficiencies (IPOPI)
IPOPI is an international not-for-profit organization that advocates for people with primary immunodeficiencies worldwide
![International Patient Organization for Primary Immunodeficiencies International Patient Organization for Primary Immunodeficiencies](https://www.x4pharma.com/wp-content/uploads/2024/03/ipopi-logo.png)
![Jeffrey Modell Foundation Jeffrey Modell Foundation](https://www.x4pharma.com/wp-content/uploads/2024/03/jmf-logo.png)
The Jeffrey Modell Foundation (JMF)
Not-for-profit organization devoted to early and precise diagnosis, meaningful treatments and ultimately cures for people with primary immunodeficiencies.
National Neutropenia Network (NNN)
Not-for-profit organization that promotes awareness, education and research for people with severe chronic neutropenia and their families
![NNN-StackedLogo-2 national neutropenia network](https://www.x4pharma.com/wp-content/uploads/2024/03/NNN-StackedLogo-2.png)
![National Organization for Rare Disorders National Organization for Rare Disorders](https://www.x4pharma.com/wp-content/uploads/2024/03/nord-logo-crop.png)
National Organization for Rare Disorders (NORD)
A not-for-profit patient advocacy organization dedicated to improving the lives of people living with rare diseases and the organizations that serve them