Management

Paula Ragan, PhD
CEO and President
Dr. Ragan has been X4’s President and Chief Executive Officer and a member of the X4 Board of Directors since July 2014. She has more than 18 years of experience building companies in the biotechnology industry. Prior to founding X4, Dr. Ragan consulted as Chief Business Officer at Lysosomal Therapeutics Inc., a private biopharmaceutical company, where she led the company’s business development activities. Prior to that, Dr. Ragan held leadership roles in corporate development and operations at Genzyme Corporation, a Sanofi company, where she led strategic partnering efforts for Genzyme’s Rare Disease business and headed the supply chain planning for Genzyme’s flagship commercial products. Other professional roles include business roles at Hydra Biosciences, Oscient Corporation and Celera Corporation. Dr. Ragan received her B.S. from Tufts University and her Ph.D. from Massachusetts Institute of Technology and completed post-doctoral studies at Harvard Medical School. Read More
Adam Mostafa
Chief Financial Officer
Mr. Mostafa has served as X4’s Chief Financial Officer since September 2018. Prior to joining X4, Mr. Mostafa served as chief financial officer of Abpro Corporation, a biotechnology company focused on antibody therapeutics. Prior to that, Mr. Mostafa was a managing director in the healthcare investment banking group at Cantor Fitzgerald, and was a senior banker in the healthcare investment banking group at Needham & Company. Prior to that, Mr. Mostafa was a vice president in the investment banking group at CRT Capital Group, and was a portfolio management associate in the global stock selection group at AQR Capital. He began his career as an analyst in the healthcare investment banking group at Salomon Smith Barney. Mr. Mostafa earned an A.B. in Economics from Brown University. Read More
E. Lynne Kelley, M.D., FACS
Chief Medical Officer
Dr. Kelley is the Chief Medical Officer at X4. She brings more than a decade of experience directing clinical development and global expansion of novel pharmaceutical products at both emerging and established life sciences companies. Dr. Kelley is a Board Certified General and Vascular Surgeon. Before joining X4, Dr. Kelley was Chief Medical Officer (CMO) of Massachusetts-based biopharmaceutical company Histogenics Corporation, where she led the development of restorative cell therapies to replace damaged cartilage and oversaw the completion of a Phase 3 clinical trial and regulatory submission for the company’s lead program. Dr. Kelley previously served as CMO of Senseonics Holdings, Inc. and held leadership positions in clinical development roles at global companies such as Becton, Dickinson and Company, Kimberly-Clark Corporation, and Boston Scientific Corporation. Dr. Kelley received her medical degree from Dartmouth Medical School and her bachelor’s degree in biology from Boston University. She trained at Dartmouth Hitchcock Hospital and Massachusetts General Hospital, and was a practicing surgeon at Yale University. Dr. Kelley was named Fellow of the American College of Surgeons, was awarded an NIH research grant at Harvard and the Marco Polo Fellowship studying at Hospital Henri Mondor of the University Paris Hospital System, and has authored numerous articles for peer-reviewed publications. Read More
Derek Meisner, J.D.
General Counsel
Derek Meisner, J.D., serves as General Counsel at X4. Mr. Meisner brings more than two decades of experience providing counsel to public and private companies across key legal and operational functions, including regulatory compliance, debt and equity financings, mergers and acquisitions, strategic partnerships and corporate governance. Most recently, Mr. Meisner held the role of General Counsel at Genocea Biosciences, a Cambridge-based, publicly traded, clinical-stage biopharmaceutical company. Prior to Genocea, he served as General Counsel of multiple Boston-based financial services firms, including prominent life science investor RA Capital Management, and he was previously a partner at the international law firm K&L Gates and Branch Chief in the Division of Enforcement of the U.S. Securities and Exchange Commission. Mr. Meisner holds a B.A. from the University of Michigan and a J.D. from the Washington College of Law at American University. Read More
Renato Skerlj, Ph.D.
Senior Vice President, Research and Development
Dr. Skerlj is Senior Vice President of Research and Development at X4. He has twenty-five years of experience leading the discovery and development of small molecule drugs to treat rare diseases, cancer, infection and neurodegenerative diseases and deep scientific expertise in the research and development of innovative, genetically-targeted treatments. Most recently, Dr. Skerlj held drug discovery and development leadership roles at Cambridge-based Lysosomal Therapeutics, Inc. Prior to that, he was interim Head of Small Molecule Discovery at Genzyme, and was part of the executive team at AnorMED, a publicly-traded company that was acquired by Genzyme in 2006. Dr. Skerlj is an inventor of both plerixafor, a stem cell mobilizer approved by the U.S. Food and Drug Administration (FDA) in 2008, and ertapenem, an anti-bacterial approved by the FDA in 2001, and has been responsible for delivering multiple drug candidates into early clinical research. He has authored 65 publications and holds 50 patents. Dr. Skerlj received his Ph.D. in Synthetic Organic Chemistry from the University of British Columbia and completed postdoctoral fellowships at the University of Oxford and Ohio State University. Read More
Mary DiBiase, PhD
Senior Vice President, Technical Operations and Quality
Dr. DiBiase is the Senior Vice President of Technical Operations and Quality at X4. She has more than 20 years of drug development and technical operations experience in both large and small organizations holding leadership roles in technical development, product operations and program management. Prior to X4 she was VP Technical Operations and Program Management at Epirus Biopharmaceuticals, a small biosimilar company working to expand access to biosimilar products across the globe. Other professional roles include VP Product Operations, Specialty Care Business Unit for Pfizer Global Supply, and multiple positions of increasing responsibility at Biogen including Sr Director CMC Management, Program Executive for Avonex® and Associate Director Pharmaceutical Science and Technology. Dr. DiBiase received her PhD from the University of Rhode Island and her B.Pharm. from the University of London. Read More
Ronny Mosston, MBA
Senior Vice President of Human Resources
Ms. Mosston is the Senior Vice President of Human Resources at X4. She has served in leadership positions in Human Resources and Patient Advocacy/Engagement at several prominent biotechnology and life sciences companies for more than 20 years, spanning disease areas such as oncology, rare disease and infertility. In addition to senior positions held at Millennium Pharmaceuticals, Takeda, and OvaScience, Ms. Mosston has provided expert consulting to executive teams at both public and private biotechnology companies to help build patient engagement and human resources strategies that align with business and cultural goals. Prior to working in life sciences, she was a Partner and Chief Operating Officer of a Boston based staffing and executive search company which became publicly traded and was acquired by a global Human Resources Consulting company. Ms. Mosston serves on the Dana Farber Patient and Family Advisory Council and previously served as its co-chair. She sits on the Executive Committee of the Joe Andruzzi Cancer Foundation, is a founding member of the MassBIO Patient Advocacy Committee and a member of the Healthcare Businesswomen’s Association (HBA). Ms. Mosston received her BS in Biology and her MBA, in Human Resources Management from Boston University. Read More
Nic Scalfarotto, DVM
Senior Vice President, Regulatory Affairs and Program Management
Dr. Scalfarotto is the Senior Vice President, Regulatory Affairs and Program Management at X4. With over 25 years of experience at biopharmaceutical companies and clinical research organizations, he has held executive roles covering multiple stages of development including solutions for treating rare and ultra-rare diseases. His experience has spanned diverse development programs covering small molecules, novel biologics, biosimilars, bio-betters, follow-on biologics, imaging agents and combination products. Initially focused on preclinical development, his regulatory career evolved in small and large corporate settings including PAREXEL, Millennium, Bristol-Myers, Eurand, Momenta, EMD Serono and GE Healthcare. He has been responsible for global regulatory development, in multiple therapeutic areas including Cardiology, Oncology, Immunology, Endocrinology, Gastroenterology, Dermatology, Rheumatology, Neurology and Biomarker development, as well as, support of licensing activities. Most recently, he held the position of Senior Vice President, Regulatory Affairs at Aegerion Pharmaceuticals, focusing on the development of products targeting rare metabolic diseases. Additionally in prior positions at three CROs (MetTrials, Chrysalis and Oread), Dr. Scalfarotto held General Management positions with encompassed such responsibilities as strategic and tactical planning, finance, operations, business development, regulatory affairs, quality assurance, information systems and facilities planning. Dr. Scalfarotto holds an undergraduate degree in biological sciences from Seton Hall University and a degree in Veterinary Medicine from the University of Bologna. Read More
Celeste DiJohnson
Vice President, Clinical Operations
Ms. Celeste DiJohnson is Vice President of Clinical Operations at X4. Ms. DiJohnson brings over 25 years of industry experience in small and large biotechnology companies and has held senior leadership roles in clinical operations and global program development and has significant success in building and leading high performing clinical development teams with broad organizational impact. She worked in multiple orphan indications in the therapeutic areas of neurology, oncology, and rare disease while at Cephalon, Sanofi Genzyme, and Sarepta, respectively. While at Sarepta, Ms. DiJohnson was instrumental in the development and approval of EXONDYS 51® (eteplirsen injection) for genetic mutations amenable to exon-skipping, which was approved by the FDA for Duchenne Muscular Dystrophy in 2016. Ms. DiJohnson received her BS degree in Biology from Shippensburg University and a Master of Psychology degree from Immaculata University and is active in her community. Read More
Tarek Ebrahim, MD
Vice President Medical Affairs, Rare Disease
Dr. Ebrahim is Vice President Medical Affairs, Rare Disease at X4. He has 17 years of extensive experience in rare diseases and a strong presence among thought leaders in the U.S. and globally. Most recently, as Executive Director, he led the Paroxysmal Nocturnal Hemoglobinuria (PNH) global team in Alexion Pharmaceuticals, where he successfully implemented effective patients’ identification strategies and medical marketing educational programs. Prior to Alexion, he spent 13 years in Genzyme/Sanofi leading U.S. and global multi-disciplinary teams focusing on developing evidence-based data for physicians’ communication and patient engagement in the field of Lysosomal Storage Disorders (LSDs). He supported global medical affairs to develop the first published therapeutic goals and disease management guideline for a rare genetic disease. He managed new product development, integrated product launches and oversaw brand management. At X4, Dr. Ebrahim is leading our medical affairs strategy, patient enrollment engagement and drive key thought leadership partnerships. He earned his bachelor’s degree in medicine and surgery from Alexandria University in Egypt, where he also received training as an anesthesiologist and the designation of Diplomat of Public Health. Read More
Brian Bowersox
Vice President, Finance
Mr. Bowersox has more than 15 years of progressive experience in finance and accounting functions, leveraging capital allocation and business transformation initiatives while helping to maximize profitability and enterprise value. Mr. Bowersox previously served in a similar role as a corporate controller at a Massachusetts-based life sciences company, Abpro, where he provided strategic financial counsel to corporate management and business partners across all functions of the organization, including business development valuations, systems implementation and optimization, annual planning and projections and effective accounting policies and principles. He received his Master’s in Business Administration at Southern New Hampshire University and his Bachelor’s in Accounting at Bryant University. Read More
 

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