Waldenstrom Macroglobulinemia

Overview 

  • Waldenstrom macroglobulinemia (WM) is a slow-growing type of non-Hodgkin lymphoma (NHL). The cancer cells make large amounts of an abnormal protein (a macroglobulin called IgM) in the blood.
  • WM is most often caused by mutations in the MYD88 genes; about 30-40% of patients also have a mutation in the CXCR4 gene.
  • X4 Pharmaceuticals is conducting a Phase 1b clinical trial, as part of a collaboration with The Leukemia & Lymphoma Society, to evaluate the study drug, mavorixafor, in combination with the marketed drug ibrutinib in patients with both MYD88 and CXCR4 mutations.

 

 

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